John Wiley & Sons Dendrimer-Based Drug Delivery Systems Cover This book focuses on the formulation and delivery of dendrimers. It offers both a comprehensive intr.. Product #: 978-0-470-46005-4 Regular price: $172.90 $172.90 In Stock

Dendrimer-Based Drug Delivery Systems

From Theory to Practice

Cheng, Yiyun (Editor)

Wiley series in drug discovery and development

Cover

1. Edition July 2012
534 Pages, Hardcover
Wiley & Sons Ltd

ISBN: 978-0-470-46005-4
John Wiley & Sons

Short Description

This book focuses on the formulation and delivery of dendrimers. It offers both a comprehensive introduction and reference to practical applications. The coverage encompasses dendritic drug delivery systems ranging from dendrimers chemistry to cellular uptake of dendritic nanoparticles. With the specific application of dendrimers in drug and biologic delivery, the text highlights their versatility in solving development issues in a wide class of drugs. Discussing all the unique opportunities, issues, and challenges involved in exploiting dendrimers for improving drug delivery, this book helps pharmaceutical and related scientists understand and work with this drug carrier.

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This book focuses on the formulation and delivery of dendrimers. It offers both a comprehensive introduction and reference to practical applications. The coverage encompasses dendritic drug delivery systems ranging from dendrimers chemistry to cellular uptake of dendritic nanoparticles. With the specific application of dendrimers in drug and biologic delivery, the text highlights their versatility in solving development issues in a wide class of drugs. Discussing all the unique opportunities, issues, and challenges involved in exploiting dendrimers for improving drug delivery, this book helps pharmaceutical and related scientists understand and work with this drug carrier.

Foreword vii
Donald A. Tomalia

Preface ix

Acknowledgments xi

Contributors xiii

About the Editor xvii

1 Dendrimer Chemistry: Supramolecular Perspectives and Applications 1
Charles N. Moorefield, Sujith Perera, and George R. Newkome

2 Physicochemical Properties of Dendrimers and Dendrimer Complexes 55
Toyoko Imae

3 The Use of Dendrimers to Optimize the Physicochemical and Therapeutic Properties of Drugs 93
Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp, and Melgardt M. de Villiers

4 Biological Properties of Phosphorus Dendrimers 139
Anne-Marie Caminade and Jean-Pierre Majoral

5 Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation 157
Mohammad Najlah, Zhengyuan Zhou, and Antony D'Emanuele

6 Improving the Biocompatibility of Dendrimers in Drug Delivery 207
Yiwen Li, Libo Zhao, and Yiyun Cheng

7 Degradable Dendrimers for Drug Delivery 239
Marc Gingras and Myriam Roy

8 Design of Stimuli-Responsive Dendrimers for Biomedical Purposes 307
Chie Kojima

9 Dendrimer-Based Gene Delivery Systems: Administration Routes and In Vivo Evaluation 329
Santander-Ortega M.J., Uchegbu I.F., and Scha¨tzlein A.G.

10 Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities 355
Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, and Eric E. Simanek

11 Dendrimer-Coated Carbohydrate Residues as Drug Delivery Trojan Horses in Glycoscience 407
Yoann M. Chabre and Rene´ Roy

12 Nuclear Magnetic Resonance Techniques in the Analysis of Pamam Dendrimer-Based Drug Delivery Systems 439
Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu, and Yiyun Cheng

13 Dendrimer-Based Medical Nanodevices for Magnetic Resonance Imaging Applications 463
Hongdong Cai, Mingwu Shen, and Xiangyang Shi

14 Dendrimer-Related Nanoparticle System for Computed Tomography Imaging 479
Chen Peng and Xiangyang Shi

Index 501
"This book should be particularly valuable for everyone working in the dendrimer area, but also for researchers in drug delivery and pharmaceutical sciences more generally. To my mind, it is clearly a book to have on your shelf!." (ChemMedChem, 1 March 2013)
YIYUN CHENG, PhD, is a Full Professor of Biomedical Engineering at the School of Life Science of East China Normal University. His research interests focus on the biomedical applications of dendrimers and other dendritic polymers. Dr. Cheng has published more than forty peer-reviewed manuscripts in such journals as Nature Materials, Chemical Society Reviews, and Journal of the American Chemical Society.