Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
1. Edition June 2012
378 Pages, Hardcover
Wiley & Sons Ltd
This book offers an essential guide to this important class of chemotherapeutic drugs. Chapters organize compounds according to their target, helping the reader understand these drugs' mechanism and how resistance can arise. The book uses an integrated "lab-to-clinic" approach covering drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects, prodrugs, and future improvements. Agents covered include quinolones, rifamycins, sulphonamides, trimethoprim, chloramphenicol, macrolides, tetracyclines, b-lactams, D-cycloserine, vancomycin, and isoniazid. This guide belongs on the bookshelves of students of pharmacy, pharmacology, and medicinal chemistry.
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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function.
Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated "lab-to-clinic" approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include:
* agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
* agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim
* agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
* agents targeting cell wall synthesis - ß-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
* * Micro-organisms - Classification; DNA Replication; Metabolic Processes (Folic Acid Synthesis); Protein Synthesis; Bacterial Cell Wall Synthesis; Bacterial Detection and Identification; Other than its mode of action, what factors determine the antibacterial activity of a drug?; The 'Post-Antibiotic Age'?
Section Two - Agents Targeting DNA
* Quinolone Antibacterial Agents
* Rifamycin Antibacterial Agents
* & Nitroimidazole Antibacterial Agents
Section Three - Agents Targeting Metabolic Processes
* Sulfonamide Antibacterial Agents
Section Four - Agents Targeting Protein Synthesis
* Aminoglycoside Antibiotics
* Macrolide Antibiotics
* Tetracycline Antibiotics
Section Five - Agents Targeting Cell Wall Synthesis
* ²-Lactam Antibiotics
* Glycopeptide Antibiotics