Short description At last: a comprehensive treaty on one of the most successful drugs ever. One of the leading figures in Aspirin-related research presents a comprehensive treaty on the history, pharmacology and the clinical applications of this amazing drug.
From the contents TABLE OF CONTENTS
1. GENERAL ASPECTS
1.1 HISTORY 1.1.1 WILLOW BARK AND LEAVES AS ANTIPYRETIC, ANTI-INFLAMMATORY ANALGESICS 1.1.2 SALICYLATES AS THE ACTIVE INGREDIENT OF WILLOW BARK AND OTHER NATURAL SOURCES 1.1.3 SYNTHESIS OF ACETYLSALICYLIC ACID AND FIRST CLINICAL STUDIES 1.1.4 MODE OF ASPIRIN ACTION 1.1.5 ANTI-INFLAMMATORY/ANALGESIC ACTIONS OF ASPIRIN 1.1.6 ASPIRIN IN THE CARDIOVASCULAR SYSTEM 1.1.7 CURRENT RESEARCH TOPICS
1.2 CHEMISTRY 1.2.1 STRUCTURES AND CHEMICAL PROPERTIES OF SALICYLATES 1.2.2 DETERMINATION OF SALICYLATES
2. PHARMACOLOGY
2.1 PHARMACOKINETICS 2.1.1 ABSORPTION AND DISTRIBUTION 2.1.2 BIOTRANSFORMATION AND EXCRETION
2.2 CELLULAR MODES OF ACTION 2.2.1 INHIBITION OF CYCLOOXYGENASES 2.2.2 COX-INDEPENDENT ACTIONS ON CELL FUNCTION 2.2.3 ENERGY METABOLISM
2.3 ACTIONS ON ORGANS AND TISSUES
2.3.1 HEMOSTASIS AND THROMBOSIS 2.3.2 INFLAMMATION, PAIN AND FEVER 2.3.3 ASPIRIN AND MALIGNANCIES
3. TOXICITY AND DRUG SAFETY
3.1 SYSTEMIC SIDE-EFFECTS
3.1.1 ACUTE AND CHRONIC TOXICITY 3.1.2 BLEEDING DISORDERS 3.1.3 SAFETY PHARMACOLOGY IN PARTICULAR LIFE SITUATIONS
3.2 ORGAN TOXICITY 3.2.1 GASTROINTESTINAL (GI) TRACT 3.2.2 KIDNEY 3.2.3 LIVER 3.2.4 AUDIOVESTIBULAR SYSTEM
3.3 NON-DOSE-RELATED (PSEUDO)ALLERGIC ACTIONS OF ASPIRIN
