1. Edition - May 2005
125.- Euro
2005. 464 Pages, Hardcover
ISBN-10: 0-471-47489-4
ISBN-13: 978-0-471-47489-0 - John Wiley & Sons






Sample Chapter

Short description
More than fifty percent of the drugs that are developed fail because they cannot be adequately delivered to the desired target. This book covers this increasingly important area in a general but not trivial way. This book offers a traditional reference book for professionals in the field, and a textbook for graduate students interested in gaining an initial overview of the field.

From the contents
Preface.

List of Contributors.

1. Factors that Impact the Developability of Drug Candidates-An Overview (Chao Han and Binghe Wang).

2. Chemical, Biochemical, and Physiological Barriers to Oral Drug Delivery (Teruna Siahaan).

3. Pathways for Drug Delivery to the Central Nervous System (Yan Zhang and Donald W. Miller).

4. Physiochemical Properties, Formulation and Drug Delivery (E. Munson).

5. Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery (William F. Elmquist).

6. Pre-Systemic and First-pass Metabolism (W. Griffith Humphreys).

7. Cell Culture Models for Drug Transport Studies (D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasabdabi, Amber M. Young, Erik Rytting, Bradley Yops and Kenneth L. Audus).

8. Prodrug Approaches to Drug Delivery (Longqin Hu).

9. Receptor-Mediated Drug Delivery (Chirstopher P. Leamon and Philip S. Low).

10. Oral Protein and Peptide Drug Delivery (Rick Soltero).

11. Metabolic Activation and Drug Targeting (Xiangming Guan).

12. Ultrasound Mediated Drug Delivery (Ka-yun Ng' and Terry O. Matsunaga).

13. Polycationic Peptides and Proteins in Drug Delivery: Focus on Non-Classical Transport (Lisa A. Kueltzo and C. Russell Middaugh).

14. Gene Therapy and Gene Delivery (Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura).

15. Parenteral Formulations for Peptide and Protein Delivery, and Monoclone Antibody Drugs (John Bontempo).

16. Pulmonary Drug Delivery - Pharmaceutical Chemistry and Aerosol Technology (Anthony J. Hickey).

17. Antibody-Directed Drug Delivery (Hervé Le Calvez, John Mountzouris, Kosi Gramatikoff and Fang Fang).

18. Efflux Transporters in Drug Excretion (Shuzhong Zhang and Marilyn E. Morris).

19. Liposome as Drug Delivery Vehicles (Guijun Wang).

20. Regulatory and IP Issues in Drug Delivery Research (Shihong Nicolaou).

Index.