Short description This multidisciplinary handbook is clearly structured and written from the viewpoint of an experienced biochemist, immunologist, and scientist. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development.
From the contents Introduction Some old and new findings on antigen processing and presentation Antigen entry routes - where foreign invaders meet antigen presenting cells Antigen processing in the context of MHC class I molecules Antigen processing for MHC Class II Antigen processing and presentation by CD1 family proteins Naturally processed self-peptides of MHC molecules Target cell contributions to cytotoxic T cell sensitivity Stimulation of antigen presenting cells: from classical adjuvants to Toll-like receptor (TLR) ligands Evolution and diversity of macrophages Macrophages - Balancing tolerance and immunity Polymorphonuclear neutrophils as antigen-presenting cells Microglial - the professional antigen presenting cells of the CNS? The contribution of B cells to autoimmune pathogenesis Dendritic cells (DCs) in immunity and maintenance of tolerance Thymic dendritic cells Antigen-presenting cells as drug targets Glossary
