|  | Kubinyi, Hugo / Müller, Gerhard (eds.)
Chemogenomics in Drug Discovery
A Medicinal Chemistry Perspective
Methods and Principles in Medicinal Chemistry (Volume 22)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - July 2004
179.- Euro
2004. XXIV, 463 Pages, Hardcover
227 Fig. (44 Colored Fig.), 15 Tab.
- Handbook/Reference Book -
ISBN-10: 3-527-30987-X
ISBN-13: 978-3-527-30987-0 - Wiley-VCH, Weinheim
Short description
The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process.
With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics.
From the contents
Introduction
GENERAL ASPECTS
Target Family-directed Masterkeys
Drug Discovery from Side Effects
Chemical Genetics in Drug Discovery
Structural Aspects of Binding Site Similarity
TARGET FAMILIES
Knowledge-based Discovery of Biological Targets
Chemical Kinomics
Kinase Inhibitors
Ion Channel Modulators
Phosphodiesterase Inhibitors
Proteochemometrics
CHEMICAL LIBRARIES
Compound Library and Template Design for GPCRs
Computational Filters in Lead Generation
Ligand-based Design of Focused Libraries
Natural Product-derived Combinatorial Libraries
Combinatorial Chemistry in the Chemical Genomics Age
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