1. Edition - February 2007
530.- Euro
2007. 1206 Pages, 3 Volumes, Hardcover
368 Fig. (126 Colored Fig.), 46 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-31150-5
ISBN-13: 978-3-527-31150-7 - Wiley-VCH, Weinheim









Short description
Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on the subject. No academic institution or pharmaceutical company can possibly miss out this highly authoritative work.

From the contents
PART I: INTRODUCTION
Chemistry and Biology -- Historial and Philosophical Aspects (Gerhard Quinkert, Frankfurt University)

PART II: USING SMALL MOLECULES TO EXPLORE BIOLOGY
Using Small Molecules to Unravel Biological Mechanisms (Tarun Kapoor, Rockefeller University)
Using Natural Products to Unravel Cell Biology (Craig Crews, Yale University)
Engineering Control Over Protein Function Using Chemistry (Kevan Shokat, UC San Francisco)
Controlling Protein Function by Caged Compounds (Carsten Schultz, EMBL Heidelberg)
Transcription Control by Small-Molecules (John Koh, University of Delaware)
Controlling Protein-Protein Interactions (Virginia Cornish, Columbia University)
Controlling Protein-Protein Interactions Using Chemical Inducers and Disrupters of Dimerization (Tim Clackson, Ariad Pharmaceuticals)
Protein Secondary Structure Mimetics as Modulators of Protein-Protein and Protein-Ligand Interactions (Andrew Hamilton, Yale University)
Expanding the Genetic Code (Masahiko Sisido, Okayama University)

PART III: DISCOVERING SMALL MOLECULE PROBES FOR BIOLOGICAL MECHANISMS
Forward Chemical Genetics (Stuart Schreiber & Steve Haggarty, Harvard University)
Reverse Chemical Genetics -- An Important Strategy for the Study of Protein Function in Chemical and Drug Discovery (Herbert Waldmann, MPI Dortmund)
Chemical Biology and Enzymology: Protein Phosphorylation as a Case Study (Phil Cole, Johns Hopkins University)
Chemical Strategies for Activity-based Proteomics (Ben Cravatt, Scripps Intitute)
The Biarsenical Tetracysteine Protein Tag: Chemistry and Biological Applications (Steve Adams, UC San Diego)
Chemical Approaches to Exploit Fusion Proteins for Functional Studies (Kai Johnsson, EPF Lausanne)

PART IV. EXPANDING THE SCOPE OF CHEMICAL SYNTHESIS
Diversity-oriented Synthesis (Derek Tan, Sloan Kettering Cancer Center)
Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides (Chaitan Khosla, Stanford University)
Expressed Protein Ligation (Tom Muir, Rockefeller University)
Chemical Synthesis of Proteins and Large Bioconjugates (Phil Dawson, Scripps Institute)
New Methods for Protein Bioconjugation (Matt Francis, UC Berkeley)
The Search for Chemical Probes to Illuminate Carbohydrate Function (Laura Kiessling, University of Wisconsin)
Chemical Clydomics as Basis for Drug Discovery (Peter Seeberger, ETH Zurich)
The Bicyclid Depsipeptide Family of Histone Deacetylase (A. Ganesan, University of Southampton)

PART V: CHEMICAL INFORMATICS

Chemical Informatics (Paul Clemons, Harvard University)
WOMBAT and WOMBAT-PK: Bioactivity Databases for Lead and Drug Discovery (Tudor Oprea, University of New Mexico)

PART VI: DRUG DISCOVERY

Managerial Challenges in Implementing Chemical Biology Platforms (Frank Douglas, MIT)
The Molecular Basis of Predicting Druggability (Andrew Hopkins, Pfizer)
The Target Family Approach (Peter Nestler, Sanofi-Aventis)
Chemical Biology of Kinases Studied by NMR Spectroscopy (Harald Schwalbe, Frankfurt University)
The Nuclear Receptor Superfamily and Drug Discovery (Kenneth Pearce, GSK)
The GPCR-7TM Receptor Target Family (Edgar Jacoby, Novartis)
Drugs Targeting Protein-Protein Interactions (Patrick Chene, Novartis)

PART VII: SYSTEMS BIOLOGY

Prediction of ADMET properties (Ulf Norinder, AstraZeneca)
Systems Biology of the JAK-STAT Signaling Pathway (Jens Timmer, Freiburg University)
Modeling Intracellular Signal Transduction Processes (Jason Haugh, NCSU)
Genome-wide Gene Expression and Application to the Analysis of T-Cell Subsets in Inflammatory Diseases (Lars Rogge, Institut Pasteur)
Scanning the Proteome for Targets of Organic Small Molecules Using Bifunctional Receptor Ligands (Nikolai Kley, GPC Biotech)

PART VIII: OUTLOOK

Chemical Biology -- An Outlook
by Günther Wess (National Research Center for Environment and Health)