Osada, Hiroyuki
Protein Targeting with Small Molecules
Chemical Biology Techniques and Applications
  1. Edition - October 2009
87.90 Euro
2009. 290 Pages, Hardcover
- Practical Approach Book -
ISBN-10: 0-470-12053-3
ISBN-13: 978-0-470-12053-8 - John Wiley & Sons
Sample Chapter
Short description
New opportunities to use small molecules both as probes for deciphering the control mechanism of living organisms and as potential leads for developing new therapeutics for disease treatment are ushering in a new era of chemical biology. Summarizing the major issues and approaches to chemical biology and the applications in drug design and development, Small Molecules for Protein Targeting provides chemical biologists and medicinal chemists with a detailed review of chemical genomics, target profiling immobilization technology, detection methods, and much more.
From the contents
Contributors.
Preface.
Chapter 1: Chemical biology based on the small molecule-protein interaction (Hiroyuki Osada).
Chapter 2: Target Profiling of Small Molecules (Leonid L. Chepelev, and Michel Dumontier).
Chapter 3: Novel application of affinity beads (Yasuaki Kabe, Mamoru Hatakeyama, Satoshi Sakamoto, Kousuke Nishio, and Hiroshi Handa).
Chapter 4: Immolization of small molecules on solid phase (Naoki Kanoh, and Hiroyuki Osada).
Chapter 5: Application of phage display technique to identify the target protein (Yoon Sun Cho and Ho Jeong Kwon).
Chapter 6: Development of fluorescent probes for small molecules (Adrian P. Neal, and Carsten Schultz).
Chapter 7: Development of small molecule ligands and inhibitors (Leonid L. Chepelev, Nikolai L. Chepelev, Hooman Shadnia, William G. Willmore, James S. Wright, and Michel Dumontier).
Chapter 8: Interaction of biological response modifier with proteins (Yuichi Hashimoto).
Chapter 9: Chemical biology of cell motility inhibitors (Tatsuro Kawamura, Mitsuhiro Kitagawa, and Masaya Imoto).
Chapter 10: Chemical biology of cell surface oligosaccarides (Prabhani U. Atukorale, Sean S. Choi, Udayanath Aich, Christopher T. Campbell, M. Adam Meledeo, and Kevin J. Yarema).
Chapter 11: Chemical genomics based on yeast genetics (Shinichi Nishimura, and Yoko Yashiroda Minoru Yoshida).
Chapter 12: Data Fact of small molecules and their target proteins (Takeo Usui, Akiko Saito, and Hiroyuki Osada).
Index.
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