Yan, Bing (ed.) Analysis and Purification Methods in Combinatorial Chemistry Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications
1. Edition - January 2004 115.- Euro 2004. 466 Pages, Hardcover ISBN-10: 0-471-26929-8 ISBN-13: 978-0-471-26929-8 - John Wiley & Sons
Short description One of the most exciting analytical events in the past decade is the rapid development of combinatorial chemistry. Analysis and Purification Methods in Combinatorial Chemistry delivers the latest in this fast-moving field. Part one of the book describes various approaches to monitor reactions on solid support and optimize reactions for library synthesis. Part two is dedicated to high-throughput analytical methods used to analyze the quality of the libraries. Part three discusses various high-throughput purification techniques. Part four applies analytical methods to post-synthesis and post-purification stages. The book contains contributions from the field's most-respected researchers and practitioners.
From the contents Preface.
Contributors.
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR (L. Lucas & C. Larive).
Chapter 2. 19F Gel-phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading (J. Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports (M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C. Enjalbal, et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL.
Chapter 7. High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications (P. Simms).
Chapter 9. Characterization of Split-Pool Encoded Combinatorial Libraries (J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY.
Cha pter 10. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J. Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis and Purification (H. Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, Diverse Phatmaceutical Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in Biomolecular Recognition (M. Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potential and Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries (C. Lipinski).
Chapter 17. High-Throughput Determination of Log D Values by LC/MS Method (J. Villena, et al.).
