|  | Testa, Bernard / Krämer, Stefanie D.
The Biochemistry of Drug Metabolism: Conjugations, Consequences of Metabolism, Influencing Factors
The Biochemistry of Drug Metabolism (Volume 2)
 1. Edition - March 2010
49.- Euro
2010. 620 Pages, Softcover
- Textbook -
ISBN-10: 3-906390-54-3
ISBN-13: 978-3-906390-54-3 - Verlag Helvetica Chimica Acta, Zürich
Short description
The second of this two-volume work completes the general characterization of drug-metabolizing enzymes and their catalyzed reactions started in Volume One. Part 4 discusses conjugation reactions and the respective enzymes, while Part 5 deals with the pharmacological and toxicological consequences of drug and xenobiotic metabolism, substantiated by compelling examples. The final two parts analyze the inter- and intra-individual factors that affect the expression and activity of drug-metabolizing enzymes, beginning with genetic factors, including the differences between animal species and polymorphisms of human drug-metabolizing enzymes. Lastly, those influencing factors that are not inscribed in the genome and which may change during a lifetime are elucidated with a particular focus on drug-drug interactions.
|
|
|
|
