1. Edition - August 2007
119.- Euro
2007. 320 Pages, Hardcover
- Monograph -
ISBN-10: 0-471-74302-X
ISBN-13: 978-0-471-74302-6 - John Wiley & Sons






Sample Chapter

Short description
Aminoglycoside antibiotics are important for treating serious bacterial infections. A number of advances in their chemistry, biochemistry and recognition have come about in the last ten-fifteen years which have led to the development of novel antibiotics and opened up new therapeutic targets for intervention. Addressing the chemistry, biology, and toxicology of aminoglycosides, Aminoglycoside Antibiotics: From Chemical Biology
to Drug Discovery brings professionals and students in the field up to date on these advances in the field and helps them fulfill the enormous potential of aminoglycodises for drug discovery and rational drug design.

From the contents
Preface.

Contributors.

1. In the Beginning There Was Streptomycin (Julian Davies).

2. The Biochemistry and Genetics of Aminoglycoside Producers (Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier).

3. Mechanisms of Aminoglycoside Antibiotic Resistance (Tushar Shakya and Gerard D. Wright).

4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics (Jinhua Wang and Cheng-Wei Tom Chang).

5. NMR Structural Studies of Aminoglycoside: RNA Interaction (R. Andrew Marshall and Joseph D. Puglisi).

6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides (Jiro Kondo and Eric Westhof).

7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome (Dale Kling, Christine Chow, and Shahriar Mobashery).

8. Metalloaminoglycosides: Chemistry and Biological Relevance (Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan).

9. Adverse Effects of Aminoglycoside Therapy (Andra E. Talaska and Jochen Schacht).

10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives (Lev Elson-Schwab and Yitzhak Tor).

11. Novel Targets for Aminoglycosides (Dev P. Arya, Nicholas Shaw, and Hongjuan Xi).

Index.