|  | Babine, Robert E. / Abdel-Meguid, Sherin S. (eds.)
Protein Crystallography in Drug Discovery
Methods and Principles in Medicinal Chemistry (Volume 20)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - November 2003
149.- Euro
2003. XVI, 262 Pages, Hardcover
131 Fig. (41 Colored Fig.), 11 Tab.
- Monograph -
ISBN-10: 3-527-30678-1
ISBN-13: 978-3-527-30678-7 - Wiley-VCH, Weinheim
Short description
Researchers from leading pharmaceutical companies present first-hand information, mostly published for the first time. They discuss strategies to derive high-resolution structures for important target protein classes, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments is also included.
A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach.
From the contents
Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes
Kinases
The Proteasome as a Drug Target
Antibiotics and the Ribosome
Strucutre-based Design of Cathepsin K Inhibitors
Structure-based Design of Potent and Selective Cdk4 Inhibitors
Crystallization and Analysis of Serine Proteases with Ecotin
X-ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs
Engineering Proteins to Promote Crystallization
High-throughput Crystallography
Micro-crystallization
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