1. Edition - October 2009
299.- Euro
2009. LX, 934 Pages, 2 Volumes, Hardcover
131 Fig. (17 Colored Fig.), 45 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-32363-5
ISBN-13: 978-3-527-32363-0 - Wiley-VCH, Weinheim








Short description
A first-stop reference for researchers and professionals that presents the complete picture on what is currently known about endogenous toxins, including their generation, mode of action, resulting disease condition, and available countermeasures.

From the contents
PART A: ENDOGENOUS TOXINS ASSOCIATED WITH EXCESSIVE SUGAR, FAT, RED MEAT OR ALCOHOL CONSUMPTION
1: Endogenous DNA damage
2: Modification of cysteine residues in protein
3: Endogenous macromolecule radicals
4: Alcohol-derived bioadducts
5: Iron from meat produces endogenous pro-carcinogen peroxides
6: Short chain sugars as endogenous toxins
7: Fructose-derived endogenous toxins
8: Cytotoxicity and oxidative stress induced by the glyceraldehyde-related Maillard reaction products
9: Estrogens as Endogenous Toxins
10: Reactive oxygen species (ROS), hypohalites (HOCI), and reactive nitrogen species (NOS)

PART B: GENETICS, ENDOGENOUS TOXINS ASSOCIATED WITH INBORN ERRORS OF METABOLISM
11: Oxalate and primary hyperoxaluria
12: Pathophysiology of endogenous toxins and their relation to in-born errors of metabolism and drug mediated toxicities
13: Mechanisms of toxicity in fatty acid oxidation disorders
14: Homocysteine as an endogenous toxin in cardiovascular disease
15: Uric acid alterations in cardiometabolic disorders and gout
16: Genetic defects in iron and copper trafficking
17: Polyglutamine neuropathies: Animal models to molecular mechanisms

PART C: EXAMPLES OF ENDOGENOUS TOXINS ASSOCIATED WITH ACQUIRED DISEASES OR ANIMAL DISEASE MODELS
18: Alcohol-induced hepatic injury
19: Ethanol-induced endotoxemia and tissue injury
20: Gut microbiota, diet, endotoxemia and disease
21: Nutrient derived endogenous toxins in the pathogenesis of Type 2 diabetes at the beta cell level
22: Endogenous toxins and susceptibility or resistance to diabetes complications
23: Serum advanced glycation end products associated with NASH and other liver diseases
24: Oxidative stress in the pathogenesis of hepatitis C
25: Oxidised low density lipoprotein cytotoxicity and vascular disease
26: Oxidative stress in breast cancer carcinogenesis
27: Lifestyle, endogenous toxins and colorectal cancer risk
28: Dopamine-derived neurotoxins and Parkinson's disease
29: Dopamine catabolism and Parkinson's disease: Role of a reactive aldehyde intermediate
30: Tetrahydropapaveroline, an endogenous dicatechol isoquinoline
31: Chemically-induced autoimmunity
32: Endogenous toxins associated with life expectancy and aging

PART D: THERAPEUTICS PROPOSED FOR DECREASING ENDOGENOUS TOXINS
33: Therapeutic potentials for decreasing the endogenous toxin homocysteine: Clinical trials
34: Prevention of oxidative stress-induced disease by natural dietary compounds: The mechanism of actions
35: Genotoxicity of endogenous estrogens
36: Design of nutritional interventions for control of cellular oxidation