1. Edition - November 2009
48.90 Euro
2009. 334 Pages, Softcover
ISBN-10: 0-470-68197-7
ISBN-13: 978-0-470-68197-8 - John Wiley & Sons








Short description
Today, metal-based drugs are commonplace in medicine. Metals in Medicine offers fundamental chemical reasoning behind the action of metal-based drugs for treating and diagnosing disease. This book examines the bonding concepts related to metallo-drugs, agents and substances interactions, as well as much more. This textbook outlines the steps from drug discovery to the marketplace. Including a supplementary website with downloadable Powerpoint slides, feature boxes, references, bibliographies, and end-of-chapter problems and exercises, this book is essential for students to clearly understand how agents work and all aspects of medicinal inorganic chemistry.

From the contents
Chapter 1. Inorganic Chemistry Basics

1.1 Crystal field theory

1.2 Molecular orbital theory

1.3 Absorption spectra of metal complexes

1.4 Magnetic properties of metal complexes

1.5 Reactions of metal complexes

1.6 Bibliography

1.7 References

1.8 Problems


Chapter 2. Metallo-Drugs and Their Action

2.1 Introduction

2.2 Proteins as Targets for Metallo-Drugs

2.3 DNA as a target for Metallo-Drugs

2.4 Reactions of Metal Complexes in the Biological Milieu.

2.5 Evaluating the Pharmacological Effects of Agents

2.6 From Discovery to the Marketplace and Beyond

2.7 Bibliography

2.8 References

2.9 Problems


Chapter 3. Cisplatin

3.1 Physical and Chemical Properties of Cisplatin

3.2 Formulation, Administration, and Pharmacokinetics

3.3 Reaction of Cisplatin in Biological Media

3.4 Uptake, Cytotoxicity, and Resistance

3.5 Interaction of Cisplatin with Cellular Targets

3.6 Bibliography

3.7 References

3.8 Problems


Chapter 4. Platinum Anticancer Drugs

4.1 Carboplatin

4.2 Oxaliplatin

4.3 New Platinum Agents

4.4 Bibliography

4.5 References

4.6 Problems


Chapter 5. Ruthenium, Titanium, and Gallium for Treating Cancer

5.1 Ruthenium for Treating Cancer

5.2 Titanium Compound for Treating Cancer.

5.3 Gallium for Treating Cancer.

5.4 Bibliography

5.5 References

5.6 Problems


Chapter 6. Gold Compounds for Treating Arthritis, Cancer, and Other Diseases

6.1 Chemistry of Gold in Biological Media

6.2 Gold Complexes for Treating Cancer

6.3 Gold Complexes for Treating AIDS and Other Diseases

6.4 Bibliography

6.5 References

6.6 Problems


Chapter 7. Vanadium, Copper, and Zinc in Medicine

7.1 Vanadium for Treating Diabetes

7.2 Copper and Alzheimer's Disease.

7.3 Copper in Wilson's and Menkes Diseases.

7.4 Zinc-Bicyclam. A Cytokine Receptor Antagonist

7.5 Bibliography

7.6 References

7.7 Problems


Chapter 8. Metal Complexes for Diagnosing Disease.

8.1 Technetium-99m in diagnostic nuclear medicine.

8.2 Metal compounds as contrast agents for MRI.

8.3 Radionuclides for palliative care and cancer treatment.

8.4 Bibliography

8.5 References

8.6 Problems.


Chapter 9. Nanomedicine

9.1 Nanoscience in Treating Disease

9.2 Nanoscience in Diagnosing Disease

9.3 Potential Health Risks of Nanoparticles

9.4 Sources

9.5 Literature Cited

9.6 Problems

Index