Short description This first problem-based approach teaches the true basics of the subject by way of everyday case studies. The contributions are presented in a pedagogically uniform and highly motivating fashion, with each chapter introducing a different biological problem taken from lab work.
From the contents YEAST-BASED CHEMICAL GENOMIC APPROACHES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation ? Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules MIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY Introduction Chemical Probes ? A Chemical Question with Biological Consequences Diversity Oriented Synthesis (DOS) Biology Oriented Synthesis (BIOS) TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATOR Introduction Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation ACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation: ASKA Technology ? Applications in Molecular Biology MODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation TARGETED PROTEIN DEGRADATION IN LIVE CELLS Introduction The Biological Problem The Chemical Approach TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation NATIVE CHEMIAL LIGATION ? A TOOL FOR CHEMICAL PROTEIN SYNTHESIS Introduction The Synthetic Challenge The Chemical Approach ? Native Chemical Ligation Chemical Biological Research/Evaluation ? The Ras-RBD Systems USING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICING Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation ELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation SEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION Introduction The Biological Problem ? Targeting DNA with Small Molecules The Chemical Approach: The Polyamide Rationale Chemical Biological Research/Evaluation ? Polyamides in Biological Applications G-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATION Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation
