|  | Scott, Peter J. H. / Hockley, Brian G.
Radiochemical Syntheses
Volume 1: Radiopharmaceuticals for Positron Emission Tomography
Wiley Series on Radiochemical Syntheses (Volume 1)
 1. Edition March 2012
109.- Euro
2012. 368 Pages, Hardcover
ISBN 978-0-470-58895-6 - John Wiley & Sons
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This book is part of a series dedicated to providing reliable methods for radiochemical reactions, including all essential information to duplicate procedures. As a first volume, it provides established, reliable synthetic methods for a large number of routinely-prepared positron emission tomography (PET) radiopharmaceuticals, commonly used in imaging for tumor studies, cardiology, and neuroscience. By giving researchers in the field necessary experimental details, the book eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information.
From the contents
Contributors ix
Foreword xvii
Preface xix
Abbreviations xxi
Part 1: Fluorine-18 Labeled Radiopharmaceuticals 1
Chapter 1: Synthesis of [18F]Fluorodeoxyglucose ([18F]FDG) 3
Michelle Richards and Peter J. H. Scott
Chapter 2: Synthesis of [18F]Sodium Fluoride ([18F]NaF) 15
Brian Hockley and Peter J. H. Scott
Chapter 3: Radiosynthesis of 3'-Deoxy-3'-[18F]Fluorothymidine ([18F]FLT) 21
Hartmuth C. Kolb, Henry Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Peter J. H. Scottii and Joseph C. Walsh
Chapter 4: Synthesis of [18F]Fluoroazomycin arabinoside (18F-FAZA) 31
Brian G. Hockley and Peter J. H. Scott
Chapter 5: Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]fluoropropyl)-2-nitroimidazole, [18F]FMISO) 41
Patrick J. Riss, Valentina Ferrari, Robbie Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio
Chapter 6: Synthesis of [18F]FPPRGD2 51
Shuanglong Liu, Frederick T. Chin, Zhen Cheng and Xiaoyuan Chen
Chapter 7: Synthesis of [18F]Fluorocholine ([18F]FCH) 61
David Kryza
Chapter 8: Clinical Manufacturing of [18F]-16-a-Fluoroestradiol ([18F]FES) 69
Piyush Kumar and John R. Mercer
Chapter 9: Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) 81
Xia Shao
Chapter 10: synthesis of 4-(2´-Methoxyphenyl)-1-[2'-(N-2''-pyridinyl)-p-[18F]fluorobenzamido]ethylpiperazine ([18F]MPPF) 87
Marion Alvarez and Didier Le Bars
Chapter 11: Synthesis of [18F]Fallypride 95
Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio
Chapter 12: Synthesis of [18F]Fluoroethyltyrosine ([18F]FET) 103
Y. Zhao, A. Alfteimi and M. Zuhayra
Chapter 13: Synthesis of [18F]Flumazenil ([18F]FZ) 111
Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, Alexander Thiel
Chapter 14: Synthesis of 6-[18F]Fluorodopamine (6-[18F]FDA) 125
Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz
Chapter 15: Synthesis of 2-([18F]fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA) 139
Hayden T. Ravert, Daniel P. Holt and Robert F. Dannals
Chapter 16: Synthesis of [18F]-Substance-P Antagonist-receptor Quantifier ([18F]SPA-RQ) 155
Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy Bormans
Part 2: Carbon-11 Labeled Radiopharmaceuticals 167
Chapter 17: SYNTHESIS OF [11C]-Choline Chloride ([11C]CHL) 169
Brian G. Hockley, Bradford Henderson and Xia Shao
Chapter 18: Synthesis of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]6-OH-BTA-1; [11C]PIB) 177
Cécile Philippe, Markus Mitterhauser and Wolfgang Wadsak
Chapter 19: Synthesis of [11C]-Meta-hydroxyephedrine ([11C]MHED) 191
Filippo Lodi, Assunta Carpinelli, Claudio Malizia and Stefano Boschi
Chapter 20: Synthesis of L-[methyl-11C]Methionine ([11C]MET) 199
Amy L. Vavere and Scott E. Snyder
Chapter 21: Synthesis of (+)-±-[11C]-Dihydrotetrabenazine ([11C]DTBZ) 213
Michael R. Kilbourn
Chapter 22: Synthesis of [11C]Flumazenil([11C]FMZ) 221
Roberto Canales-Candela, Patrick J. Riss and Franklin I. Aigbirhio
Chapter 23: Synthesis of [11C]-Hexadecanoic Acid ([11C]Palmitic Acid) 233
Adam C. Runkle, Xia Shao and Peter J. H. Scott
Chapter 24: Synthesis of [O-Methyl-11C]Metomidate ([11C]MTO) 245
István. Boros and Franklin I. Aigbirhio
Chapter 25: Synthesis of [11C]Carfentanil ([11C]CFN) 257
Louis Tluczek and Xia Shao
Chapter 26: Synthesis of [carbonyl-11C]WAY-100635 265
J. D. Andersson, S. Nag, R. Krasikova, V.W. Pike and C. Halldin
Chapter 27: Synthesis of [11C]Raclopride 275
Xia Shao
Chapter 28: Synthesis of 3-Amino-4-[2-(N-Methyl-N-[11C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([11C]DASB) 285
Daniela Haeusler, Markus Mitterhauser and Wolfgang Wadsak
Chapter 29: Synthesis of [11C]Acetate 297
Filippo Lodi, Claudio Malizia and Stefano Boschi
Chapter 30: Synthesis of N-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28) 305
Qi-Huang Zheng, Min Wang and Bruce H. Mock
Part 3: Other Radiopharmaceuticals 313
Chapter 31: Synthesis of [13N]Ammonia ([13N]NH3) 315
Peter J. H. Scott
Chapter 32: Synthesis of [68Ga]Gallium DOTA-(TYR3)-Octreotide Acetate ([68Ga]DOTATOC) 321
Harald Eidherr, Friedrich Girschele, Markus Mitterhauser and Wolfgang Wadsak
Appendix 1: Supplier Information 335
Index 339
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