1. Edition - January 2005
192.- Euro
2005. XIV, 440 Pages, Hardcover
372 Fig., 35 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-30517-3
ISBN-13: 978-3-527-30517-9 - Wiley-VCH, Weinheim






Sample Chapter



Short description
Asymmetric catalysis represents still one of the major challenges in modern organic chemistry. Besides the well-established asymmetric metal-complex-catalysed syntheses and biocatalysis, the use of "pure" organic catalysts turned out to be an additional efficient tool for the synthesis of chiral building blocks. In this handbook, the experienced authors from academia and industry provide the first overview of the important use of such metal-free organic catalysts in organic chemistry. With its comprehensive description of numerous reaction types, e.g., nucleophilic substitution and addition reactions as well as cycloadditions and redox reactions, this book targets organic chemists working in industry and academia, and deserves a place in every laboratory.

From the contents
Introduction
General Mechanistic Considerations
Nucleophilic Substitution at Aliphatic Carbon
Nucleophilic Addition to Electron-deficient C=C Double Bonds
Nucleophilic Addition to C=N Double Bonds
Nucleophilic Addition to C=O Double Bonds
Nucleophilic Addition to Unsaturated Nitrogen
Cycloaddition Reactions
Protonation of Enolates and Tautomerization of Enols
Oxidation
Reduction of Carbonyl Compounds
Kinetic Resolution of Racemic Alcohols and Amines
Desymmetrization and Kinetic Resolution of Anhydrides
Large-Scale Applications
Appendix: Tabular Survey of Organo-Catalysts, Synthesis and Application