1. Edition - August 2008
229.- Euro
2008. XXVI, 658 Pages, Hardcover
358 Fig. (30 Colored Fig.), 50 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-31820-8
ISBN-13: 978-3-527-31820-9 - Wiley-VCH, Weinheim







Content

Sample Chapter

Index



Short description
This one-stop reference for every scientist working in the field covers more than 25 compound classes. The only comprehensive overview on the field addresses biochemical aspects and applications as well as compounds with therapeutic potential.

From the contents
BIOCHEMISTRY AND BIOPHYSICS
Investigations on Fluorine-labeled Ribonucleic Acids by 19F-NMR Spectroscopy
8-Oxo-7,8-dihydro-2'-deoxyguanosine, a major DNA oxidation product
Modified DNA Bases: Probing Base Pair Recognition by Polymerases
2'-Deoxyribose Modified Nucleoside Triphosphates and their Recognition by DNA Polymerases
Pyrimidine Dimers: UV-induced DNA Damage
Locked Nucleic Acids: Properties, Applications and Perspectives
Studies on the synthesis and properties of oligonucleotides incorporating modified nucleobases capable for the formation of Watson and Crick type base pairs
The Properties of 4'-Thionucleosides
S-Adenosyl-L-methionine and related compounds
BIOTECHNOLOGY
5-Subsituted nucleosides in biochemistry and biotechnology
Universal base analogues and their applications to biotechnology
MEDICINAL CHEMISTRY
The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology and Medicinal Chemistry
Synthesis, chemical properties and biological activities of cyclic bis(3'-5')diguanylic acid (c-di-GMP) and its analogues
Siderophore Biosynthesis Inhibitors
Synthesis and Biological Activity of Selected Carbocyclic Nucleosides
4'-C-Ethynyl-2'-deoxynucleosides
Modified nucleosides as Selective Modulators of Adenosine Receptors for Therapeutic Use
The Design of Forodesine HCl and Other Purine Nucleoside Phosphorylase Inhibitors
Formycin and Analogues: Purine Nucleoside Phosphorylase Inhibitors and their Potential Application in Immunosuppression and cancer
1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd)
Syntheses and Biological Activity of Neplanocin and Analogues
Clitocine and Its Analogs
ANTITUMORALS AND ANTIVIRALS
Capecitabine Preclinical Studies: From Discovery to Translational Research
Tenofovir and Adefovir as Antiviral Agents
Clofarabine: Design to Approval