|  | Sipe, Jean D. (ed.)
Amyloid Proteins
The Beta Sheet Conformation and Disease
 1. Edition July 2005
420.- Euro
2005. XXV, 774 Pages, 2 Volumes, Hardcover
129 Fig., 41 Tab.
- Handbook/Reference Book -
ISBN 978-3-527-31072-2 - Wiley-VCH, Weinheim
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| Short description
A first-stop reference on amyloid diseases and the first to present a systematic overview of all known fibril-forming proteins, including their biochemical characteristics and pathophysiology, these two volumes are a valuable tool for researchers and clinicians alike.
From the contents
PART I Overview of Amyloidosis and Amyloid Proteins
Brief history of amyloidosis
Anatomic and clinical clues to in vivo mechanisms of amyloidogenesis
PART II Protein Structure and the Beta Pleated Sheet Conformation
Brief history of the beta pleated sheet conformation including glossary of terms
PART III Protein Folding, Unfolding and Refolding
Thermodynamics and protein folding
The role of post-translational chemical modifications in amyloid fibril formation
Lipid modulators of protein misfolding and aggregation
Extracellular matrix-heparan sulfate proteoglycans
Serum amyloid P component: Structural features and amyloid recognition
Apolipoprotein E
PART IV Pathways to Amyloid Fibril Formation
Partially folded intermediates in the fibrillation of natively unfolded proteins
Partially folded intermediates, random coil
Chemical interactions in amyloid fibril formation
PART V Pathophysiology of Amyloid Fibril Formation
Oligomers and cellular toxicity
Fibrils and organ dysfunction
Brain dysfunction associated with amyloid fibrils and other aggregated proteins
PART VI Amyloid Proteins
Beta amyloid protein
Prion protein
Familial dementia
Immunoglobulin
Transthyretin
Apolipoprotein, AApoAII and Amyloid A
Gelsolin
Lysozyme
Fibrinogen
Beta-2-microglobulin
Cystatin C
IAPP and Others
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