1. Edition - April 2007
142.- Euro*
2007. 286 Pages, Hardcover
ISBN-10: 0-470-05766-1
ISBN-13: 978-0-470-05766-7 - John Wiley & Sons

* Series price on request at service@wiley-vch.de





Sample Chapter

Short description
Acetaldehyde-Related Pathology brings together contributions from experts working on all aspects of acetaldehyde-related pathology in order to better understand the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated. The book describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signaling pathways implicated in alcohol-related pathology. In-depth, round-table discussions by an international array of scientists from major laboratories worldwide involved in studies of acetaldehyde-related pathology are also featured.

From the contents
Symposium on Acetaldehyde-related pathology: bridging the trans-disciplinary divide, held at the Novartis Foundation, London 5-7th September.

Editors: Derek J. Chadwick (Organizer) and Jamie Goode

This symposium is based on a proposal made by Victor Preedy, Peter Emery and Mikko Salaspuro

Peter Emery Chair's introduction.

David W. Crabb and Suthat Liangpunsakul Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes.

Discussion.

Richard A. Deitrich, Dennis Petersen and Vasilis Vasiliou Removal of acetaldehyde from the body.

Discussion.

Shih-Jiun Yin and Giia-Sheun Peng Acetaldehyde, polymorphisms and the cardiovascular system.

Discussion.

Jun Ren Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.

Discussion.

Mikko Salaspuro Interrelationship between alcohol, smoking, acetaldehyde and cancer.

Discussion.

Hiroto Matsuse, Chizu Fukushima, Terufumi Shimoda, Sadahiro Asai and Shigeru Kohno Effects of acetaldehyde on human airway constriction and infl ammation.

Discussion.

Helmut K. Seitz The role of acetaldehyde in alcohol-associated cancer of the gastrointestinal tract.

Discussion.

Robert Tardif The determination of acetaldehyde in exhaled breath.

Discussion.

Mostofa Jamal, Kiyoshi Ameno, Mitsuru Kumihashi, Weihuan Wang, Ikuo Uekita and Iwao Ijiri Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain.

Discussion.

Ville Salaspuro Pharmacological treatments and strategies for reducing oral and intestinal acetaldehyde.

Discussion.

Victor R. Preedy, David W. Crabb, Jaume Farrés and Peter W. Emery Alcoholic myopathy and acetaldehyde.

Discussion.

Onni Niemelä Acetaldehyde adducts in circulation.

Discussion.

General discussion.

M. Apte, J. McCarroll, R. Pirola and J. Wilson Pancreatic MAP kinase pathways and acetaldehyde.

Discussion.

Shivendra D. Shukla, Youn Ju Lee, Pil-hoon Park and Annayya R. Aroor Acetaldehyde alters MAP kinase signalling and epigenetic histone modifi cations in hepatocytes.

Discussion.

Paul J. Thornalley Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.

Discussion.

C. J. Peter Eriksson Measurement of acetaldehyde: what levels occur naturally and in response to alcohol?

Discussion.

Final discussion.

Contributors Index.

Subject Index.