Short description Provides a much-needed survey of the mechanisms and pathways of programmed cell death - the primary target of cytotoxic cancer therapies. The first comprehensive treatment of this topic that is central to the development of novel cancer therapies.
From the contents Volume I. Apoptosis signaling I.1. Death receptor: -CD95 signaling -The TRAIL receptor-ligand system -TNF-induced cell death -cFLIP -Dependence receptors and apoptosis I.2. Mitochondria: -Role of mitochondrial proteins in apoptosis -Omi/HtrA2 -Apoptosis inducing factor (AIF) I.3. Effector systems: -Caspases -Apoptosome I.4. Bcl-2 family: -Bcl-2 family proteins -Bax, Bak and Bid -Puma/Noxa I.5. IAPs: -Inhibitor of apoptosis proteins (IAPs) -Targeting the survivin pathway I.6. Survival pathways: -NFkB -Pi3K/AKT -Ras/Raf I.7. Oncogenes/Tumor suppressor genes: -P53 -P73 -RB I.8. Modulators: -Calcium signaling I.9. Lysosomes and non-apoptotic pathways I.10. Phagocytosis/ Clearance: -Phagocytosis of apoptotic cells -Clearance of apoptotic cells
Volume II. Apoptosis in cancer and cancer therapy II.1. Models systems: -Mouse models II.2. Molecular diagnosis: -Molecular imaging in cancer research -Microarrays II.3. Cellular stress, DNA damage & repair: -Stress signaling in cancer -Hypoxia in cancer -DNA damage-induced apoptosis -DNA repair II.4. Molecular targets and therapeutic aspects: -Therapeutic Modulation of Apoptosis -Targeting caspases in cancer -Cancer therapy by reactivation of the p53 apoptosis pathway -Small molecule inhibitors of IAPs -Targeting HSP90 -Targeting the PI3K/Akt pathway -Ceramide Signaling -HDAC inhibitors -Exploiting apoptosis pathways for glioblastoma therapy -Radiation therapy and apoptosis -Tumor angiogenesis
