Short description Written by one of the main contributors to progress in protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from the contents.
From the contents PART A THEORETICAL BASIS AND EXPERIMENTAL TECHNIQUES Introduction Techniques Principles of X-ray Diffraction by a Crystal Methods for Solving the Phase Problem Model Building and Refinement Time-resolved X-ray Crystallography
PART B CASE STUDIES FOR DIFFERENT KINDS OF X-RAY CRYSTAL STRUCTURE DETERMINATION OF BIOMACROMOLECULES Space Group Determination and Data Reduction Phase Determination by MIRAS Technique Phase Determination by MAD Technique Phase Determination by Molecular Replacement Difference Fourier Technique Map Improvement by NCS Averaging and other Methods Automated Model Building Structure Validation and PDB-Submission
