1. Edition - August 2005
710.- Euro
2005. 1886 Pages, 4 Volumes, Hardcover
501 Fig. (124 Colored Fig.), 158 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-31184-X
ISBN-13: 978-3-527-31184-2 - Wiley-VCH, Weinheim







Sample Chapter



Competence Network "Biopharmaceuticals"

Short description
A unique and comprehensive introduction to recently developed technologies, showing paradigm shifts in the health care system and how these changes are reflected in industrial research. With authors from the world's most famous academic institutes and biotech companies.

From the contents
Volume 1

INTRODUCTION
PART I: BIOPHARMACEUTICALS USED IN MOLECULAR MEDICINE
Genes & genomes - correlation between genes, diseases & biopharmaceuticals
siRNA - the magic bullet & other gene therapeutical approaches
Mobilis in mobile - human embryonic stem cells & other sources for cell therapy


Volume 2

PART II: BIOPHARMACEUTICALS AND THEIR MODE OF ACTION
The clotting cascade - lysis, coagulation & a fine-tuned balance
Errare humanum est - what causes cancer & how to selectively fight tumors
Mundus vult decipi - high mutation rates of HIV & new paradigms for treatment
PART III: IMPROVING THE DEVELOPMENT OF BIOPHARMACEUTICALS
Citius, altius, fortius - acceleration by high throughput & ultra-HT
Early target validation - knock-out mice & more
Revolution by evolution - rational design for desire & the scientific art of optimization


Volume 3

PART IV: PRODUCTION OF BIOPHARMACEUTICALS
The industry's workhorses - mammalian expression systems
A ripe and blooming market - biopharmaceuticals from transgenic animals & plants
Alea non iacta est - improving established expression systems
When success raises its ugly head - outsourcing to uncork the capacity bottleneck
PART V: BIOPHARMACEUTICALS USED FOR DIAGNOSTICS AND IMAGING
From hunter to craftsman - engineering antibodies with nature's universal toolbox
Find, fight & follow - target-specific troica from Mother Nature's Pharmacopoiea
Getting insight - sense the urgency for early diagnostics


Volume 4

PART VI: ADVANCED APPLICATION ROUTES FOR BIOPHARMACEUTICALS
Getting inside - quest for the best & how to improve delivery
Pathfinder - new ways for peptides, proteins & Co
Via mala - the stony road of DNA delivery: back-pack, feed-back & pay-back
Getting beyond - rocket science & science fiction
PART VII: FROM TRANSCRIPTION TO PRESCRIPTION
Opening the therapeutic window - between systemic toxicity & lack of efficacy
Happy end - claim to fame & approval
PART VIII: FROM BENCH TO BEDSIDE - THE AFTERMATHS
Think big & dealmaking for growth - global changes in the health-care sector
News & views - quo vadis, biopharmaceuticals?
Small molecules - light at the end of the tunnel or back to the roots?