1. Edition - April 2009
165.- Euro
2009. XX, 370 Pages, Hardcover
69 Fig. (9 Colored Fig.), 17 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-32074-1
ISBN-13: 978-3-527-32074-5 - Wiley-VCH, Weinheim






Content

Sample Chapter

Index



Short description
Is the correctly placed sugar residue the "magic methyl" of biopharmaceuticals? Leading experts present basic facts and case studies on the importance of post-translational modifications for pharmaceutical proteins.

From the contents
1 Post translational modifications in the context of therapeutic proteins; an introductory overview (Walsh)
2 Protein glycosylation; the basic science (Brookes)
3 Mammalian cell lines and glycosylation; a case study (Butler)
4 Antibody glycosylation (Jefferis)
5 Gonadotropins and the importance of glycosylation (Ulloa-Aguirre)
6 Yeast glycosylation and engineering in the context of therapeutic proteins (Sethuraman)
7 Insect cell glycosylation patterns in the context of biopharmaceuticals (Jarvis)
8 Getting Bacteria to glycosylate (Kowarik, Feldman)
9 Glycoengineering of Erythropoietin (Elliott)
10 Glycoengineering: Cerezyme as a case study (Van Patten, Edmunds)
11 Carboxylation and Hydroxylation (Brown, Stenberg)
12 C-Terminal a-Amidation (Mehta, Carpenter)
13 Disulfide bond formation (Collett)
14 Engineering in a PTM: PEGylation (Bonora, Veronese)