3. Edition - November 2004
97.90 Euro
2004. 560 Pages, Hardcover
ISBN-10: 0-471-47878-4
ISBN-13: 978-0-471-47878-2 - John Wiley & Sons






Sample Chapter

Short description
This fully revised Third Edition of a world-renowned classic provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms. With a new full-color, enlarged page design, this edition offers the most readable, up-to-date, and thorough introduction to the field for biologists. All new features include special boxes, enhanced use of real examples, and expanded problem sets with answers provided on the book's dedicated Web site (www.wiley.com/bioinformatics). A glossary and appendix of sample file formats round out the book's reader-friendly, hands-on treatment.

From the contents
Foreword (Lee Hood).

Preface.

Contributors.

PART ONE: BIOLOGICAL DATABASES.

1. Sequence Databases (Rolf Apweiler).

2. Mapping Databases (Peter S. White and Tara C. Matise).

3. Information Retrieval from Biological Databases (Andreas D. Baxevanis).

4. Genomic Databases (Tyra G. Wolfsberg).

PART TWO: ANALYSIS AT THE NUCLEOTIDE LEVEL.

5. Predictive Methods Using DNA Sequences (Enrique Blanco and Roderic Guigó).

6. Predictive Methods Using RNA Sequences (David Mathews and Michael Zuker).

7. Sequence Polymorphisms (James C. Mullikin and Stephen T. Sherry).

PART THREE: ANALYSIS AT THE PROTEIN LEVEL.

8. Predictive Methods Using Protein Sequences (Yanay Ofran and Burkhard Rost).

9. Protein Structure Prediction and Analysis (David Wishart).

10. Intermolecular Interactions and Biological Pathways (Gary D. Bader and Anton J. Enright).

PART FOUR: INFERRING RELATIONSHIPS.

11. Assessing Pairwise Sequence Similarity: BLAST and FASTA (Andreas D. Baxevanis).

12. Creation and Analysis of Protein Multiple Sequence Alignments (Geoffrey J. Barton).

13. Sequence Assembly and Finishing Methods (Nancy F. Hansen, Pamela Jacques Thomas and Gerard G. Bouffard).

14. Phylogenetic Analysis (Fiona S. L. Brinkman).

15. Computational Approaches in Comparative Genomics (Andreas D. Baxevanis).

16. Using DNA Microarrays to Assay Gene Expression (John Quackenbush).

17. Proteomics and Protein Identification (Mark R. Holmes, Kevin R. Ramkissoon and Morgan C. Giddings).

PART FIVE: DEVELOPING TOOLS.

18. Using Perl to Facilitate Biological Analysis (Lincoln D. Stein).

Appendices.

Glossary. Index.