1. Edition - January 2009
119.- Euro
2009. 398 Pages, Hardcover
- Professional Book -
ISBN-10: 0-470-13406-2
ISBN-13: 978-0-470-13406-1 - John Wiley & Sons






Sample Chapter

Short description
This is the first book of its kind to summarize and review the increasingly important field of genetic therapy with respect to the latest immunological advances in the lab and clinic. The topic is approached from a vector and target organ point of view, rather than from the perspective of specific diseases. This provides scientists, physicians, and students with a powerful tool for comparing vectors and target organs side-by-side, making choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues involved in developing gene therapies.

From the contents
1. The immunology of gene transfer: an overview (David Lillicrap).

2. Innate immune responses to nucleic acids (Ishii and Akira).

3. The anti-viral Innate immune response (Daniel Muruve).

U. Calgary, Canada.

4. Immune responses to adenoviral vectors (Dmitry M. Shayakhmetov).

5. Immune responses to lentiviral vectors (Lung-Ji Chang).

6. Immune responses to adeno-associated virus vectors (Hildegund Ertl).

7. Immunology after in utero and neonatal gene transfer (Simon Waddington).

8. Immunology of hepatic gene transfer (Roland Herzog).

9. Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases (Pedro Lowenstein).

10. Immunology of cutaneous gene transfer (Soosan Ghazizadeh).

11. Immune responses to pulmonary gene therapy (Terence Flotte).

12. Induction of immune tolerance through gene transfer to hematopoietic stem cells (John Iacomini).

13. Reconstitution of the immune system by gene therapy (Adrian Thasher).

14. Genetics of the Immune Response to Proteins Expressed After Gene Transfer (Jay Lozier).

15. Immune modulation and transient suppression strategies (Valder Arruda).

16. Gene therapy for autoimmune diseases (Nicholas Giannoukakis).

17. Engineering of viral capsids to evade the host immune system (.

Hildegard Büning).