1. Edition - March 2002
490.- Euro
2002. XXXI, 1114 Pages, 2 Volumes, Hardcover
1046 Fig., , 73 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-30509-2
ISBN-13: 978-3-527-30509-4 - Wiley-VCH, Weinheim









Short description
This two-volume handbook is an unbeatable source of information for anyone seeking a mechanism-based and application-oriented approach to every facet of current research. A must-have for synthetic, medicinal and combinatorial chemists working in chemistry, pharmaceutical research and material science.

From the contents
GENERAL ASPECTS
Combinatorial Chemistry in Drug Discovery
Principles of Combinatorial Chemistry
Solid and Soluble Supports for Heterogenous Systems
Linkers for Solid Phase Synthesis
Encoding Technologies
Instrumentation for Combinatorial Chemistry

SYNTHETIC CHEMISTRY
Radical Chemistry
Nucleophilic Substitution
Electrophilic Substitution
Elimination
Addition to CC Multiple Bonds Except CC Bond Formation
Addition to CX Multiple Bonds Except CO Double Bonds
Chemistry of the Carbonyl Group
Oxidation Except CC Double Bonds
Reduction Except CC Double Bonds
Cycloaddition
Main Group Organometallics
Enolates and Related Species
Transitions Metal Catalyzed Formation of Single Bonds
Metathesis and Related Processes for CC Multiple Bond Formation

SPECIAL SYNTHETIC TOPICS
Libraries of Natural Products
Synthesis of Heterocyclic Systems
Multicomponent Reactions
Combinatorial Chemistry of Oligosaccharides

DESIGN OF COMBINATORIAL LIBRARIES
Design Criteria
Estimation of Physicochemical Parameters
Virtual Libraries and Modeling
Case Study: Medicinal Chemistry

NOVEL APPLICATIONS OF COMBINATORIAL CHEMISTRY
Combinatorial Chemistry in the Fine Chemical Industry
High Throughput Process Research
Combinatorial Approaches to Catalyst Discovery
Case Study: Combinatorial Catalyst Discovery
Combinatorial Aspects of Material Research
Combinatorial Principles of Biology and Their Potential Applications to Drug Discovery