1. Edition - November 2010
119.- Euro
2010. 492 Pages, Hardcover
ISBN-10: 0-470-40691-7
ISBN-13: 978-0-470-40691-5 - John Wiley & Sons






Sample Chapter

Short description
This book provides readers with an understanding of chiral separations, and offers a handy guide for selecting the best separation method, saving considerable time and cost in product development. It also discusses chiral separations in the biotechnological and pharmaceutical industries, as well as for agriculture and food applications. Specific topics covered include high pressure liquid chromatography (HPLC), nuclear magnetic resonance (NMR), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), computational studies, and enantiomer selection. This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students.

From the contents
Contributors.

Preface.

1 Overview of Chiral Separations (Satinder Ahuja).

2 Regulatory & Development Considerations of Chiral Compounds (Robert L. Zeid).

3 Basic Considerations in Method Development for Chiral Compounds (Satinder Ahuja).

4 Separations of Chiral Compounds on Polysaccharide Columns (Clinton W. Amoss and Norbert M. Maier).

5 Chiral Separations by Various Techniques (Jian G. Ning).

6 Chiral Discrimination Study for Polysaccharide Based Chiral Stationary Phase (Yun K. Ye).

7 Comparison of Chiral Chromatographic Columns for Pharmaceuticals (Gregory K. Webster).

8 Chiral Separation Screens for Pharmaceutical Analysis and Purification in an Industrial Laboratory Environment (Robert DePianta, Kenneth Douville, Beverly Nickerson, and Ricardo E. Borjas).

9 The Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases (Volker Schurig).

10 Separations of Chiral Compounds by SFC (Ziqiang Wang).

11 Chiral Separations by Capillary Electrophoresis (Debby Mangelings and Yvan Vander Heyden).

12 High-Throughput Screening and Method-Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE (Hasret Ates, Debby Mangelings and Yvan Vander Heyden).

13 Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers (Christopher J. Welch, Derek H. Henderson, William R. Leonard, Mirlinda Biba, Mike Zacuto, Fred Fleitz, Amude Kassim, Cheng-yi Chen, and Peter Sajonz).

14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology (Gregory K. Webster and William J. Buttner).

15 Chirality of Biomolecules and Biotechnology Products (Satinder Ahuja).

Index.