1. Edition - April 2010
122.- Euro
2010. 360 Pages, Hardcover
ISBN-10: 0-470-77274-3
ISBN-13: 978-0-470-77274-4 - John Wiley & Sons






Sample Chapter

Short description
In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular attention is paid to the preclinical screening of drug cardiotoxicity. Cardiotoxicity of Non-Cardiovascular Drugs provides an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy, and cardiovascular disease.

From the contents
Preface.

List of Contributors.

Abbreviations. .

1. Mitochondrial Dysfunction In Cell Injury and Cardiotoxicity (Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabò, Marcella Canton).

2. Cardiovascular Liabilities of Drugs: Regulatory Aspects (Claudio Arrigoni).

3. Cellular Mechanisms, Molecular Targets, and Structure-Function Relationships In Drug-Induced Arrhythmias: The Case Of Antihistamines, Psychoactive Drugs, and Antimicrobial Agents (Maria Virginia Soldovieri and Maurizio Taglialatela).

4. Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the Problem in Children (Rebecca Scully, Louis Pruitt, Steven E. Lipshultz).

5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings (Joseph R. Carver and Chaitali J. Desai).

6. Diagnostic Aspects of Cardiovascular Toxicity of Antitumor Drugs (Michael S. Ewer, Thomas M. Suter).

7. Cardiovascular Toxicity of Antitumor Drugs: Translating Molecular Mechanisms into Clinical Facts (Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni, and Giorgio Minotti).

8. NSAID Action and the Foundations for Cardiovascular Toxicity (Anna L. Blobaum and Lawrence J. Marnett).

9. Cardiovascular toxicities of NSAIDS: Epidemiologic aspects (Antonio González-Pérez, Luis Alberto García Rodriguez).

10. Cardiovascular Toxicities of Life-Saving Drugs: Antiviral Therapy (James J. Kohler & William Lewis).

Index.