2. Edition - May 2010
132.- Euro
2010. 848 Pages, Hardcover
- Handbook/Reference Book -
ISBN-10: 0-471-74107-8
ISBN-13: 978-0-471-74107-7 - John Wiley & Sons






Sample Chapter

Short description
Electrospray Mass Spectrometry: Fundamentals, Instrumentation, and Applications, Second Edition is an extensively updated version of the original guide. It explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole ion trap, magnetic, time-of-flight, and Fourier transform ion cyclotron resonance instruments. It introduces new fields (proteomics, metabolomics, etc.) that have flourished largely due to electrospray mass spectrometry. Encompassing fundamentals, instrumentation, applications, and analytical aspects, this is a key reference for researchers using electrospray mass spectrometry and for scientists in the biotech and pharmaceutical industries.

From the contents
Foreword: Desorption Ionization and Spray Ionization: Connections and Progress (R. Graham Cooks).

Foreword to the First Edition (John B. Fenn).

Preface (Richard B. Cole).

Contributors.

Part I Fundamentals of ES.

1. On the Mechanism of Electrospray Ionization Mass Spectrometry (ESIMS) (Paul Kebarle and Udo H. Verkerk).

2. Selectivity in Electrospray Ionization Mass Spectrometry (Nadja B. Cech and Christie G. Enke).

3. Electrochemistry of the Electrospray Ion Source (Gary J. Van Berkel and Vilmos Kertesz).

4. ESI Source Design (Andries P. Bruins).

Part II Fundamentals of MALDI.

5. MALDI Ionization Mechanisms: an Overview (Richard Knochenmuss).

6. The Development of Matrix-Assisted Laser Desorption/Ionization Sources (Peter B. O'Connor).

7. A Comparison of MALDI Matrices (Mahmud Hossain and Patrick A. Limbach).

8. MALDI Imaging Mass Spectrometry (Alain Brunelle and Olivier Laprevote).

Part III ES and MALDI Coupling to Mass Spectrometry Instrumentation.

9. Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap, and Orbitrap Mass Analyzers (Mark E. Bier).

10. Time-of-Flight Mass Spectrometry (Robert J. Cotter).

11. Fourier Transform Ion Cyclotron Resonance and Magnetic Sector Analyzers for ESI and MALDI (Jeremy J. Wolff and I. Jonathan Amster).

12. Ion Mobility-Mass Spectrometry (John A. McLean, J. Albert Schultz, and Amina S. Woods).

Part IV Practical Aspects of ES and MALDI.

13. ESI, APCI, and MALDI A Comparison of the Central Analytical Figures of Merit: Sensitivity, Reproducibility, and Speed (Thomas R. Covey, Bradley B. Schneider, Hassan Javaheri, J.C. Yves LeBlanc, Gordana Ivosev, Jay J. Corr, and Peter Kovarik).

14. Charge State Distributions in Electrospray and MALDI (Yan Li and Richard B. Cole).

15. Probing Noncovalent Interactions by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization (Sonal Mathur, Alexis Nazabal, and Renato Zenobi).

16. Ion Activation Methods for Tandem Mass Spectrometry (Kristina Hakansson and John S. Klassen).

17. Dissociation of Even-Electron Ions (Carlos Afonso, Richard B. Cole, and Jean-Claude Tabet).

Part V Biological Applications of ES and MALDI.

18. The Role of Mass Spectrometry for Peptide, Protein, and Proteome Characterization (A. Jimmy Ytterberg, Jason Dunsmore, Shirley H. Lomeli, Mario Thevis, Yongming Xie, Rachel R. Ogorzalek Loo, and Joseph A. Loo).

19. Carbohydrate Analysis by ESI and MALDI (David J. Harvey).

20. Applications of ESI and MALDI to Lipid Analysis (Xianlin Han).

21. In Vitro ADME Profiling and Pharmacokinetic Screening in Drug Discovery (Daniel B. Kassel).

Index.