1. Edition - August 2009
175.- Euro
2009. XXX, 503 Pages, Hardcover
82 Fig. (16 Colored Fig.), 35 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-32331-7
ISBN-13: 978-3-527-32331-9 - Wiley-VCH, Weinheim






Content

Sample Chapter

Index



Short description
By addressing both drug efficiency and drug safety, this modern practical reference shows how each aspect shapes the key decisions for assessing the risk/benefit ratio of any novel compound during the early drug development stages, using both in vitro and in silico methods.

From the contents
PART 1: Introduction: The one Airplane that Flies - Selection of the Right one Molecule for Clinical use.
1 Process logistics, testing strategies and automation aspects
2 Prediction of drug-likeness and its integration
3 Integrative risk assessment
PART 2: ADME Profiling: What is Drug Likeness?
4 Solubility and Aggregation
5 In silico tools and in vitro HTS approaches to determine lipophilicity during the drug discovery process
6 Membrane permeability - measurement and prediction in drug discovery
7 Drug Metabolism and Reactive Metabolites
8 Drug-Drug Interactions: Screening for liability and assessment of risk
9 Plasma Protein Binding and Volume of Distribution: Determination, Prediction and Use in Early Drug Discovery
10 Putting it all together
PART 3: Safety Profiling: What is Considered Safe in the Clinic?
11 Genetic Toxicity: in vitro Approaches for Hit and Lead Profiling
12 In vitro Safety Pharmacology Profiling: An important tool to decrease attrition
13 Knowledge-based and Computational Approaches to in vitro Safety Pharmacology
PART 4: Organ Specific Toxicity
14 Discovery Toxicology Screening: Predictive, In Vitro Cytotoxicity
15 Predicting Drug-Induced Hepatotoxicity: In Vitro, In Silico, and In Vivo Approaches
16 Should cardiosafety be ruled by hERG inhibition? Early testing scenarios and integrated risk assessment
17 Haematotoxicity: in vitro and ex vivo compound profiling
18 Profiling Adverse Immune Effects
19 In Vitro Phototoxicity Testing: A Procedure Involving Multiple Endpoints