 Benjamin W. Lee, Rajib Schubert, Yuk Kee Cheung, Federico Zannier, Qian Wei, Daniele Sacchi, Samuel K. Sia* Longer and stronger: Engineered multivalent polypeptides were used to increase and tune the adhesion strength of cells to surfaces. Monodisperse polypeptides containing programmable valencies of a cell-adhesion sequence were synthesized (with up to 80 repeats of the RGD sequence; see schematic illustration). The multivalent cell-adhesion polypeptides provided strong resistance to cellular delamination under shear. Online veröffentlicht, DOI: 10.1002/anie.200906482 |
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