04-24-2012
A New Lease on Life

04-12-2012
VIP: Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologs While Sparing Paralogous Proteases

03-27-2012
Focusing on Neglected Diseases

03-27-2012
Repurposing existing drugs: new hope against TB

03-22-2012
VIP: Characterization of Plasmodium Liver Stage Inhibition by Halofuginone

03-12-2012
VIP: Effects of Cyclic Lipodepsipeptide Structural Modulation on Stability, Antibacterial Activity, and Human Cell Toxicity

03-02-2012
ChemistryOpen: First Issue!

02-10-2012
VIP: Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

02-04-2012
VIP: Fluorogenic Peptide-Based Substrates for Monitoring Thrombin Activity

01-24-2012
VIP: Engineering and Functionalization of the Disulfide-Constrained Miniprotein Min-23 as a Scaffold for Diagnostic Applications

12-23-2011
VIP: Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

12-08-2011
Roth Describes Changing Pharma Landscape as Patent Cliff Looms

11-21-2011
VIP: Aspirin Analogues as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors: Synthesis, Nitric Oxide Release, Molecular Modeling, and Biological Evaluation as Anti-Inflammatory Agents

11-10-2011
Philip S. Portoghese, Editor-in-Chief of J. Med. Chem., Steps Down at the End of 2011

11-04-2011
VIP: Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography

10-18-2011
VIP: Development of Isoxazoline-Containing Peptidomimetics as Dual α_vβ₃ and α₅β₁ Integrin Ligands

10-13-2011
2011 CNRS Bronze Medal Awarded to Karine Alvarez

10-13-2011
Rainer Metternich to Lead the Small Molecules Research Program at Roche

10-13-2011
VIP: Insights into Matriptase-2 Substrate Binding and Inhibition Mechanisms by Analyzing Active-Site-Mutated Variants

10-13-2011
VIP: Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

10-13-2011
VIP: Understanding of Molecular Substructures that Contribute to hERG K⁺ Channel Blockade: Synthesis and Biological Evaluation of E-4031 Analogues

10-11-2011
VIP: From a Library of MAG Antagonists to Nanomolar CD22 Ligands

10-11-2011
VIP: From Catalysts to Bioactive Organometallics: Do Grubbs Catalysts Trigger Biological Effects?

10-11-2011
VIP: Rofecoxib Analogues Possessing a Nitric Oxide Donor Sulfohydroxamic Acid (SO₂NHOH) Cyclooxygenase-2 Pharmacophore: Synthesis, Molecular Modeling, and Biological Evaluation as Anti-inflammatory Agents

10-11-2011
VIP: Urolithin as a Converging Scaffold Linking Ellagic Acid and Coumarin Analogues: Design of Novel Potent Protein Kinase CK2 Inhibitors

10-08-2011
VIP: A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents

10-08-2011
VIP: Exhaustive Fluorine Scanning toward Potent p53–Mdm2 Antagonists

10-08-2011
VIP: Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis

10-05-2011
2011 Nobel Prize in Physiology or Medicine goes to Beutler, Hoffmann, Steinman

09-14-2011
VIP: Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K_2P9.1 (TASK-3)

08-29-2011
VIP: Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

07-28-2011
VIP: (S)- and (R)-Fluoxetine as Native Markers in MS Binding Assays Addressing the Serotonin Transporter

07-14-2011
VIP: Synthesis and Structure–Activity Relationships of a Class of Sodium Iodide Symporter Function Inhibitors

07-05-2011
VIP: Cell-Free HIV-1 Virucidal Action by Modified Peptide Triazole Inhibitors of Env gp120

06-16-2011
VIP: Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

05-13-2011
VIP: Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABA_A Receptors

04-22-2011
World Malaria Day: April 25th

04-19-2011
VIP: Evidence for the Existence of a Specific G-Protein-Coupled Receptor Activated by Guanosine

04-19-2011
VIP: Inhibition of Histone Demethylases by 4-Carboxy-2,2'-Bipyridyl Compounds

04-07-2011
VIP: Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes

03-29-2011
ChemMedChem 04/2011: Women in Chemistry (IYC 2011)

03-23-2011
World TB Day 2011: March 24

03-17-2011
VIP: Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts

03-16-2011
VIP: Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

03-11-2011
VIP: Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) γ/δ Agonists with High Potency and in vivo Efficacy

03-10-2011
VIP: Discovery and Biological Activity of 6BrCaQ as an Inhibitor of the Hsp90 Protein Folding Machinery

02-08-2011
ChemMedChem at the 10^th Winter Conference on Medicinal and Bioorganic Chemistry, January 23–27, 2011, Steamboat Springs, Colorado (USA)

02-02-2011
ChemMedChem 02/2011: Rare and Neglected Diseases

02-02-2011
VIP: BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

01-25-2011
VIP: Pyrido[1,2-a]benzimidazole-Based Agents Active Against TB, MDR-TB, and XDR-TB

01-19-2011
VIP: A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors

01-16-2011
VIP: Revealing Atropisomer Axial Chirality in Drug Discovery

01-04-2011
ChemMedChem Gets a New Editor

11-11-2010
VIP: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Δ₈–Δ₇ Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity

11-08-2010
VIP: Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1

10-28-2010
ChemMedChem 11/2010: 25 Years of Anti-HIV Research

10-26-2010
VIP: Asborin Inhibits Aldo/Keto Reductase 1A1

10-26-2010
VIP: Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue–Dendrimer Conjugate in C26 Tumor Bearing Mice

10-26-2010
VIP: Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

10-06-2010
VIP: Molecular Assembly of Multifunctional ^99mTc Radiopharmaceuticals Using "Clickable" Amino Acid Derivatives

09-29-2010
VIP: Target Profiling of a Small Library of Phosphodiesterase 5 (PDE5) Inhibitors using Chemical Proteomics

09-22-2010
Wiley and ChemMedChem at the International Symposium on Medicinal Chemistry 2010 in Brussels

09-17-2010
VIP: Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors

09-02-2010
VIP: Synthesis and Evaluation of Bombesin Analogues Conjugated to Two Different Triazolyl-Derived Chelators for ^99mTc Labeling

08-30-2010
ChemMedChem 09/2010: Fighting Cancer

08-19-2010
VIP: The Active Core in a Triazole Peptide Dual-Site Antagonist of HIV-1 gp120

08-09-2010
ChemMedChem Author Guidelines Updated!

08-03-2010
ChemMedChem's Success Recognized by Thompson Reuters: Editorial Team Interview Appears in ScienceWatch

08-03-2010
VIP: High-Resolution Crystal Structure of a Lasso Peptide

08-03-2010
VIP: Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

06-27-2010
VIP: Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors

06-17-2010
New 2009 Impact Factor: 3.232

06-17-2010
VIP: Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

06-15-2010
VIP: Discovery of a Class of Diketopiperazines as Antiprion Compounds

06-15-2010
VIP: Homology Modelling of the GABA Transporter and Analysis of Tiagabine Binding

06-15-2010
VIP: HTS and Rational Drug Design to Generate a Class of 5-HT_2C-Selective Ligands for Possible Use in Schizophrenia

06-15-2010
VIP: Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)

06-15-2010
VIP: Jostling for Position: Optimizing Linker Location in the Design of Estrogen Receptor-Targeting PROTACs

05-22-2010
VIP: The Role of Fluorine Atoms in a Fluorinated Prostaglandin Agonist

05-22-2010
VIP: Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

04-23-2010
Arun K. Ghosh Awarded the 2010 IUPAC-Richter Prize

04-12-2010
VIP: Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4-c]quinoline-1-one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors

03-22-2010
VIP: Azides Derived from Colchicine and Their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug

03-18-2010
VIP: A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety

03-18-2010
VIP: Highly Potent Modulation of GABA_A Receptors by Valerenic Acid Derivatives

03-18-2010
VIP: Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL

03-09-2010
VIP: Anticancer Activity of Vitamin E-Derived Compounds in Murine C6 Glioma Cells

01-23-2010
VIP: Lectin-Based Drug Design: Combined Strategy to Identify Lead Compounds using STD NMR Spectroscopy, Solid-Phase Assays, and Cell Binding for a Plant Toxin Model

01-15-2010
VIP: Pro-oxidant Properties of AZT and other Thymidine Analogues in Macrophages: Implication of the Azido Moiety in Oxidative Stress

01-15-2010
VIP: Selective Pharmacophore Models of Dopamine D₁ and D₂ Full Agonists Based on Extended Pharmacophore Features

01-15-2010
VIP: Upgrading a Natural Product: Inhibition of Human β-Tryptase by Cyclotheonamide Analogues

01-12-2010
New Editorial Board and International Advisory Board Members

01-12-2010
VIP: Chelator Fragment Libraries for Targeting Metalloproteinases

11-19-2009
Thalidomide: a Revival

11-13-2009
VIP: Comparison of Structure- and Ligand-Based Virtual Screening Protocols Considering Hit List Complementarity and Enrichment Factors

11-13-2009
VIP: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones

11-13-2009
VIP: How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase

11-05-2009
VIP: Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors

11-04-2009
Steven Ley Awarded the 2009 Heinrich Wieland Prize

10-27-2009
ChemMedChem 11/2009: Computer Power!

10-22-2009
VIP: Interaction of Artemisinins with Oxyhemoglobin Hb–Fe^II, Hb–Fe^II, CarboxyHb–Fe^II, Heme–Fe^II, and Carboxyheme Fe^II: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

09-29-2009
ChemMedChem 10/2009: Tackling Tumors!

08-31-2009
ChemMedChem 09/2009: Shockingly Hot!

06-25-2009
Going for Impact!

10-23-2008
Giordano Giacomello Medal to G. Tarzia

08-28-2008
Ley, Seeberger, and Kubinyi Awarded

10-08-2007
Nobel Prize in Physiology or Medicine 2007 to Capecchi, Evans, and Smithies

06-15-2007
ChemMedChem in Web of Science

12-01-2006
First Volume of ChemMedChem Completed

10-02-2006
RNA Interference Earns Fire, Mello Nobel Prize

07-11-2006
ChemMedChem now accepted in MEDLINE

10-04-2005
Nobel Prize in Medicine/Physiology to Marshall/Warren