John Wiley & Sons Molecular and Biochemical Toxicology Cover Written as an advanced text for toxicology students, this book is much more than an introduction and.. Product #: 978-1-119-04241-9 Regular price: $167.29 $167.29 Auf Lager

Molecular and Biochemical Toxicology

Smart, Robert C. / Hodgson, Ernest


5. Auflage Januar 2018
1040 Seiten, Hardcover
Wiley & Sons Ltd

ISBN: 978-1-119-04241-9
John Wiley & Sons

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Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.

* Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies
* Uses a didactic approach with basic biological or theoretical background for the methodology presented
* Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology
* Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts
* "A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses" - BTS Newsletter review of the 4th edition


List of Contributors

Chapter 1: Molecular and Biochemical Toxicology: Definition and Scope
Ernest Hodgson and Robert C. Smart

Chapter 2: Molecular Techniques for the Study of Gene Function
Yoshiaki Tsuji and Robert C. Smart

Chapter 3: Transcriptomics
B. Alex Merrick

Chapter 4: Proteomics
Michael B. Bereman

Chapter 5: Metabolomics
Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, Timothy R. Fennell

Chapter 6: Cellular Techniques
Sharon A. Meyer and Barbara A. Wetmore

Chapter 7: Basic Concepts of Molecular Epidemiological Research Methods
Cathrine Hoyo, David A. Skarr and Randy L. Jirtle

Chapter 8: Phase I and Phase II Metabolism and Metabolic Interactions; A Summary
Ernest Hodgson

Chapter 9: Structure, Mechanism and Regulation of Cytochromes P450
Darryl C. Zeldin, Matthew L. Edin and John M. Seubert

Chapter 10: Polymorphisms in Phase I and Phase II Genes and Outcomes
Yoshiaki Tsuji, Edward L. Croom and Ernest Hodgson

Chapter 11: Cellular Transport and Elimination
David S. Miller and Ronald Cannon

Chapter 12: Nuclear Receptors.
Seth Kullman, William S. Baldwin and Gerald A. LeBlanc

Chapter 13: Mechanisms of Cell Death
Mac Law and Susan Elmore

Chapter 14: Mitochondrial Dysfunction

Chapter 15: Reactive Oxygen Species: Reactive Metabolites and Toxicity
Elizabeth L. MacKenzie and Yoshiaki Tsuji

Chapter 16: DNA Damage and Mutagenesis
Zhigang Wang

Chapter 17: DNA Repair
Isabel Mellon

Chapter 18: Carcinogenesis
Robert C. Smart

Chapter 19: Molecular Mechanisms of Respiratory Toxicity
James C. Bonner

Chapter 20: Molecular Mechanisms of Hepatotoxicity
Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer and Angela L. Slitt

Chapter 21: Molecular Mechanisms of Renal Toxicology
Lawrence H. Lash

Chapter 22: Molecular Mechanisms of Neurotoxicity
Kimberly P. Keil, Marianna Stamou and Pamela J. Lein

Chapter 23: Molecular Mechanisms of Immunotoxicity
Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang and David A. Lawrence

Chapter 24: Molecular Mechanisms of Reproductive Toxicity
Ayelet Ziv-Gal, Catheryne Chiang, and Jodi A. Flaws

Chapter 25: Molecular Mechanisms of Developmental Toxicity
Antonio Planchart

Chapter 26:Computational and Molecular Approaches to Risk Assessment
Richard S. Judson, John Wambaugh, Kristin Isaacs, Russell S. Thomas

Chapter 27: Nanotoxicology
James C. Bonner

Chapter 28: Developmental Origins of Health and Disease
Michael Cowley

Chapter 29: Exposome.
Stephen M. Rappaport

Robert C. Smart, PhD, is the William Neal Reynolds Professor of Toxicology, Director of Graduate Programs, and Director of the Center for Human Health and the Environment at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book.

Ernest Hodgson, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Toxicology and Agromedicine at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

R. C. Smart, North Carolina State University; E. Hodgson, North Carolina State University