Wiley-VCH, Weinheim Inflammation Cover Starting with the molecular basis of inflammation, the book continues with inflammation in infectiou.. Product #: 978-3-527-33899-3 Regular price: $466.36 $466.36 Auf Lager


From Molecular and Cellular Mechanisms to the Clinic

Cavaillon, Jean-Marc / Singer, Mervyn (Herausgeber)


1. Auflage November 2017
1250 Seiten, Hardcover

ISBN: 978-3-527-33899-3
Wiley-VCH, Weinheim


Starting with the molecular basis of inflammation, the book continues with inflammation in infectious diseases and the relationship between inflammation and chronic diseases. The final part of the work is devoted to tissue healing and options for therapeutic interventions.

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The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage.
The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions.
A must have for clinicians and biomedical researchers alike.

1. INFLAMMATION THROUGH THE AGES: an historical perspective

2. PAMPs
3. DAMPs
4. Bacterial toxins
5. Venoms
6. Inflammatory substances (asbestos, silica, nanoparticles?)
7. Toll-like receptors
8. Nod-like and RIG-like receptors
9. Synergism

10. Monocytes/macrophages
11. Neutrophils
12. Mast cells
13. Eosinophils
14. Dendritic cells
15. NK cells
16. Innate lympho cells
17. Th9
18. Th17
19. Platelets
20. Epithelial cells
21. Cell death

22. IL-1 superfamily and Inflammasome
23. TNF superfamily
24. IL-17
25. IL-6 superfamily
26. Other inflammatory cytokines (e.g. IL-12, IL-15, IFN¿¿
27. Chemokines and chemotaxis
28. Lipid mediators
29. Free radicals
30. Proteases
31. Neuromediators

32. Immediate vascular response
33. Adhesion to endothelial cells, and migration
34. Adjuvant and adaptive immune response
35. Inflammation and coagulation
36. Fever: Mediators and mechanisms
37. Pain

38. Allergy and inflammation
39. Sepsis and SIRS
40. Autoimmunity
41. Psoriasis and other skin inflammatory diseases
42. Rheumatoid arthritis and other inflammatory articular diseases
43. Crohn?s disease and other inflammatory bowel diseases
44. Transplantation
45. Lungs inflammatory diseases (COPD, CF, ALI?)
46. Obesity
47. Diabetes and other auto-inflammatory diseases
48. Neurodegenerative diseases and inflammation
49. Cancer and inflammation
50. Atherosclerosis51. Ischemia/reperfusion
52. Genetic susceptibility (SNP)
53. Genetic deficiencies

54. Acute phase proteins
55. Anti-inflammatory cytokines
56. Soluble receptors and natural antagonists
57. Leukocyte reprogramming
58. Resolvin & Co
59. Glucorticoids
60. Neuromediators
61. Healing

62. Biomarkers
63. Imaging inflammation in vivo
64. Non steroid anti-inflammatory drugs
65. Targeting inflammatory cytokines
66. Novel targets for drug development
67. Probiotics
69. Natural Products as source of anti-inflammatory drugs
Jean-Marc Cavaillon is professor and Head of the Unit "Cytokines and Inflammation" at Institut Pasteur (Paris). He has been President (1998?2000) of the "International Endotoxin and Innate Immunity Society". He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of "Cytokine" (2002-2009).
Jean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book "Sepsis and non-infectious inflammation: from biology to critical care" (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books.

Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.