1. Auflage - Januar 2006
169,- Euro
2006. XXXI, 575 Seiten, Hardcover
262 Abb., , 39 Tab. 
- Handbuch/Nachschlagewerk -
ISBN-10: 3-527-31257-9
ISBN-13: 978-3-527-31257-3 - Wiley-VCH, Weinheim

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Probekapitel



Kurzbeschreibung
The first authoritative overview of past and current strategies, this resource spans all important drug classes and therapeutic fields. Includes a table of all commercially successful drug analogs and compares them in terms of chemical structure, mode of action and patentability.

Aus dem Inhalt
Introduction
GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY
Analogues as a Means of Discovering New Drugs
Drug Likeness and Analogue-Based Drug Discovery
Privileged Structures and Analog-Based Drug Discovery
SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES
Development of Anti-Ulcer H2-Receptor Histamine Antagonists
Esomeprazole in the Framework of Proton-Pump Inhibitor Development
The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole
Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors
Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers
Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors
Case Study of Lacidipine in the Research of New Calcium Antagonists
Selective Beta-Adrenergic Receptor-Blocking Agents
Case Study: "Esmolol Stat" [1]
Development of Organic Nitrates for Coronary Heart Disease
Development of Opioid Receptor Ligands
Stigmines
Structural Analogues of Clozapine
Quinolone Antibiotics: The Development of Moxifloxacin
The Development of Bisphosphonates as Drugs
Cisplatin and its Analogs for Cancer Chemotherapy
The History of Drospirenone
Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues
Corticosteroids: From Natural Products to Useful Analogues