Kurzbeschreibung The first authoritative overview of past and current strategies, this resource spans all important drug classes and therapeutic fields. Includes a table of all commercially successful drug analogs and compares them in terms of chemical structure, mode of action and patentability.
Aus dem Inhalt Introduction GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY Analogues as a Means of Discovering New Drugs Drug Likeness and Analogue-Based Drug Discovery Privileged Structures and Analog-Based Drug Discovery SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES Development of Anti-Ulcer H2-Receptor Histamine Antagonists Esomeprazole in the Framework of Proton-Pump Inhibitor Development The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors Case Study of Lacidipine in the Research of New Calcium Antagonists Selective Beta-Adrenergic Receptor-Blocking Agents Case Study: "Esmolol Stat" [1] Development of Organic Nitrates for Coronary Heart Disease Development of Opioid Receptor Ligands Stigmines Structural Analogues of Clozapine Quinolone Antibiotics: The Development of Moxifloxacin The Development of Bisphosphonates as Drugs Cisplatin and its Analogs for Cancer Chemotherapy The History of Drospirenone Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues Corticosteroids: From Natural Products to Useful Analogues
