1. Auflage - Februar 2007
185,- Euro
2007. XXI, 439 Seiten, Hardcover
221 Abb. (22 Farbabb.), 26 Tab. 
- Monographie -
ISBN-10: 3-527-31456-3
ISBN-13: 978-3-527-31456-0 - Wiley-VCH, Weinheim

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Probekapitel



Kurzbeschreibung
The first overview of mass spectrometry-based pharmaceutical analysis, this reference is the key to high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. Contains contributions from leading pharma companies and pharmaceutical research institutions.

Aus dem Inhalt
Mass Spectrometry in Bioanalysis - Methods, Principles and Instrumentation
Drug Screening Using Gel Permeation Chromatography Spin Columns Coupled with ESI-MS
ALIS: An Affinity Selection-Mass Spectrometry System for the Discovery and Characterization of Protein-Ligand Interactions
Library Screening Using Ultrafiltration and Mass Spectrometry
Continuous-Flow Systems for Ligand Binding and Enzyme Inhibition Assays Based on Mass Spectrometry
Frontal Affinity Chromatography - Mass Spectrometry for Ligand Discovery and Characterization
MS-Binding Assays - an Alternative to Radioligand Binding
Laser Desorption Assays - MALDI-MS, DIOS-MS, and SAMDI-MS
Tethering: Fragment-Based Drug Discovery by Mass Spectrometry
Interrogation of Noncovalent Complexes by ESI-MS: A Powerful Platform for High Throughput Drug Discovery
Quantification of Protein-Ligand Interactions in Solution by H/D Exchange (PLIMSTEX)
Protein-Targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)
Mass Spectrometry in Early Pharmacokinetic Investigations