1. Auflage - März 2009
122,- Euro
2009. 340 Seiten, Hardcover
- Monographie -
ISBN-10: 0-470-72723-3
ISBN-13: 978-0-470-72723-2 - John Wiley & Sons

Preis inkl. Mehrwertsteuer zzgl. Versandkosten.





Probekapitel

Kurzbeschreibung
In the last decade, DNA sequencing costs have decreased 50 fold, and further cost reductions are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics and Genomics describes the automation technology currently used in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also provides researchers, graduate students, and engineers with the current technological limitations that can be viewed as an emerging market rather than a research bottleneck.

Aus dem Inhalt
Preface.

List of Contributors.

About the Editors.

SECTION 1 FUNDAMENTALS OF MOLECULAR AND CELLULAR BIOLOGY

1 The Central Dogma: From DNA to RNA, and to Protein (Takashi Ohtsuki, Masahiko Sisido).

2 Genomes to Proteomes (Ellen A. Panisko, Igor Grigoriev, Don S. Daly, Bobbie-Jo Webb-Robertson and Scott E. Baker).

SECTION 2 ANALYSIS VIA AUTOMATION.

3 High-Throughput DNA Sequencing (Tarjei S. Mikkelsen).

4 Modeling a Regulatory Network Using Temporal Gene Expression Data: Why and How (Sophie L`ebre and Gäelle Lelandais)?

5 Automated Prediction of Protein Attributes and Its Impact on Biomedicine and Drug Discovery (Kuo-Chen Chou).

6 Molecular Interaction Networks: Topological and Functional Characterizations (Xiaogang Wu and Jake Y. Chen).

SECTION 3 DESIGN VIA AUTOMATION.

7 DNA Synthesis (Jingdong Tian).

8 Computational and Experimental RNA Nanoparticle Design (Isil Severcan, Cody Geary, Luc Jaeger, Eckart Bindewald, Wojciech Kasprzak and Bruce A. Shapiro).

9 New Paradigms in Droplet-Based Microfluidics and DNA Amplification (Michael L. Samuels, John Leamon, Jonathan Rothberg, Ronald Godiska,Thomas Schoenfeld and David Mead).

10 Synthetic Networks (Jongmin Kim).

SECTION 4 INTEGRATION.

11 Molecular Modeling of CYP Proteins and its Implication for Personal Drug Design (Jing-Fang Wang, Cheng-Cheng Zhang, Jing-Yi Yan, Kuo-Chen Chou and Dong-Qing Wei).

12 Recent Progress of Bioinformatics in Membrane Protein Structural Studies (Hong-Bin Shen, Jun-Feng Wang, Li-Xiu Yao, Jie Yang and Kuo-Chen Chou).

13 Trends in Automation for Genomics and Proteomics (Gil Alterovitz, Roseann Benson, Marco Ramoni and Dmitriy Sonkin).

Index.