|Cho-Chung, Yoon S. / Gewirtz, Alan M. / Stein, C. A. (Hrsg.)|
Transcriptional and Translational Strategies for Silencing Gene Expression
Annals of the New York Academy of Sciences
1. Auflage Juli 2006
2006. 284 Seiten, Softcover
ISBN 978-1-57331-609-5 - John Wiley & Sons
Preis inkl. Mehrwertsteuer zzgl. Versandkosten.
The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides. The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides.
Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing in mammalian cells, transcription factor decoys, and modified oligonucleotide hybridization and genetic insertion.
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