1. Auflage - November 2006
139,- Euro
2006. XIII, 305 Seiten, Hardcover
150 Abb. (10 Farbabb.), 2 Tab. 
- Praktikerbuch -
ISBN-10: 3-527-31396-6
ISBN-13: 978-3-527-31396-9 - Wiley-VCH, Weinheim

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Probekapitel



Kurzbeschreibung
Written by one of the main contributors to progress in protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology will benefit from the contents.

Aus dem Inhalt
PART A THEORETICAL BASIS AND EXPERIMENTAL TECHNIQUES
Introduction
Techniques
Principles of X-ray Diffraction by a Crystal
Methods for Solving the Phase Problem
Model Building and Refinement
Time-resolved X-ray Crystallography

PART B CASE STUDIES FOR DIFFERENT KINDS OF X-RAY CRYSTAL STRUCTURE DETERMINATION OF BIOMACROMOLECULES
Space Group Determination and Data Reduction
Phase Determination by MIRAS Technique
Phase Determination by MAD Technique
Phase Determination by Molecular Replacement
Difference Fourier Technique
Map Improvement by NCS Averaging and other Methods
Automated Model Building
Structure Validation and PDB-Submission