1. Auflage - Oktober 2011
139,- Euro
2011. XX, 370 Seiten, Hardcover
91 Abb. (21 Farbabb.), 34 Tab. 
- Handbuch/Nachschlagewerk -
ISBN-10: 3-527-32891-2
ISBN-13: 978-3-527-32891-8 - Wiley-VCH, Weinheim

Preis inkl. Mehrwertsteuer zzgl. Versandkosten.





Inhalt

Probekapitel

Index



Kurzbeschreibung
Discusses peptide-specific issues as well as five case studies of new and recent peptide drugs from the preclinical to the clinical stage. In doing so, it beautifully exemplifies the modern translational approach in drug development.


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Preface

PART I: The Academia - Market Bouncing of Peptide Drugs - Challenges and Strategies in Translational Research with Peptide Drugs

PEPTIDES AS LEADS FOR DRUG DISCOVERY
Introduction
Overview of Process for Transforming Peptides to Peptidomimetics
HCMV Protease
HCV Protease
Herpes Simplex Virus
Renin
HIV
Conclusions

MARKETING ANTIMICROBIAL PEPTIDES: A CRITICAL ACADEMIC POINT OF VIEW
Introduction
Basic Research: Antimicrobial Peptides
Patents
Potential Applications of AMPs
Technology Transfer: Valorization, Licensing, or Spin-Off Creation
Spin-Off Creation: An Academic Point of View

ORAL PEPTIDE DRUG DELIVERY: STRATEGIES TO OVERCOME CHALLENGES
Introduction
Challenges Associated with Oral Petide Delivery
Strategies to Overcome the Barriers of the Gastrointestinal Tract
Conclusions

RATIONAL DESIGN OF AMPHIPATHIC ALPHA-HELICAL AND CYCLIC BETA-SHEET ANTIMICROBIAL PEPTIDES: SPECIFICITY AND THERAPEUTIC POTENTIAL
Introduction to Antimicrobial Peptides
Antimicrobial and Hemolytic Activities of Amphipathic Alpha-Helical Antimicrobial Peptides: Mechanisms and Selectivity
Structure-Activity Relationship Studies of Amphipathic Alpha-Helical and Cyclic Beta-Sheet Antimicrobial Peptides: Optimization of Pathogen Selectivity and Prevention of Host Toxicity
Commercialization of Antimicrobial Peptides
Therapeutic Potential

CONOTOXIN-BASED LEADS IN DRUG DESIGN
Introduction
Conotoxin Classification and Targets
Conotoxins as Drug Leads
Conclusions

PLANT ANTIMICROBIAL PEPTIDES: FROM BASIC STRUCTURES TO APPLIED RESEARCH
Introduction
The Diversity of Plant Antimicrobial Peptides: Focusing on Tissue Localization and Plant Species Distribution
Possible Structural Folds Found in Plant AMPs to Date
New Biotechnological Products Produced from Plant Peptides

PART II: Peptide Drugs' Translational Tales - Peptide Drugs Before, Through and After Industry Pipelines

OMIGANAN PENTAHYDOCHLORIDE: A NOVEL, BROAD-SPECTRUM ANTIMICROBIAL PEPTIDE FOR TOPICAL USE
Omiganan: A Novel Anti-Infective Agent for Topical Indications
Structure and Mechanism of Action
Spectrum of Activity
Preclinical Efficacy Studies
Preclinical Toxicology Studies
Clinical Studies
Conclusions

TURNING ENDOGENOUS PEPTIDES INTO NEW ANALGESICS: THE EXAMPLE OF KYOTORPHIN DERIVATIVES
Introduction
Peptides as Future Drug Candidates
Central Nervous System Anagesic Peptides
Endogeneous Opioid Systems
Strategies to Deliver Analgesic Peptides to the Brain
Development of New Opioid-Derived Peptides
Kyotorphin - The Potential of an Endogenous Dipeptide
New KTP Derivatives
Assessing BBB Permeability with Peptide - Membrane Partition Studies
Kyotorphines: Partition to the Membrane and Enhanced Analgesic Activity
Academia and Pharmaceutical Industry: Friends or Foes?

THE DEVELOPMENT OF ROMIPLOSTIM - A THERAPEUTIC PEPTIBODY USED TO STIMLATE PLATELET PRODUCTION
Introduction
Thrombopoietin and c-Mpl
Discovery and Optimization of Romiplostim
Pharmacodynamics (PD) and Pharmacokinetics (PK) of Romiplostim
A Brief ITP Primer
Romiplostim Clinical Data
Safety and Other Insights Gained from Romiplostim Design and Development

HIV VS HIV: TURNING HIV-DERIVED PEPTIDES INTO DRUGS
Introduction
HIV-1 Envelope Protein
HIV Entry and Its Inhibition
HIV-1 Fusion Inhibitors: From Bench to Clinical Administration
New Strategies for Creating New HIV Fusion Inhibitor Peptides
Drug-Resistance and Combination Therapy
Concluding Remarks

SIFUVIRTIDE, A NOVEL HIV-1 FUSION INHIBITOR
Ideal Drug Target HIV-1 pg41
Structure-Based Drug Design of Sifuvirtide
High Potency of Sifuvirtide
Limited Drug Resistance
Enhancement of the Efficiency of Sifuvirtide by Biomembrane Selectivity
Pharmacokinetics of Sifuvirtide with Long Half-Life
Stratification of Monotherapy
20 mg Sifuvirtide Once Daily vs. 100 mg T10 Twice Daily
Conclusions and Discussion

PART III: Whither Peptide Drugs? Peptides Shaping the Future of Drug Development

ENDOGENOUS PEPTIDES AND THEIR RECEPTORS AS DRUG DISCOVERY TARGETS FOR THE TREATMENT OF METABOLIC DISEASE
Centrally Secreted Neuropeptide Systems
Peripherally Secreted Neuropeptides
Summary

TRANSLATION OF MOTILIN AND GHRELIN RECEPTOR AGONISTS INTO DRUGS FOR GASTROINTESTINAL DISORDERS
Introduction
Motilin and Ghrelin Receptor Agonists Under Development
Translational Value of Preclinical Assays
Clinical Translation: Selecting the "Right" Patient Population
Clinical Development of Motilin and Ghrelin Receptor Agonists
Conclusions

OF MICE AND MEN: TRANSLATIONAL RESEARCH ON AMYLIN AGONISM
Overview of Amylin Physiology
Pramlintide: An Amylin Agonist
Amylin Agonism: Translational Research in Insulin-Dependent Diabetes
Amylin Agonism: Translational Research in Obesity

PEPTIDES AND POLYPEPTIDES AS IMMUNOMODULATORS AND THEIR CONSEQUENTIAL THERAPEUTIC EFFECT IN MULTIPLE SCLEROSIS AND OTHER AUTOIMMUNE DISEASES
Introduction
Peptides as Antigens and Vaccines
Peptides as Immunomodulators
Development of Copolymer 1 - A Polypeptide Immunomodulator Drug for the Treatment of Multiple Sclerosis
Additional Immunomodulatory Peptides as Drug Candidates
Summary and Concluding Remarks

DEVELOPMENT OF ANTIBODY FRAGMETNS FOR THERAPEUTIC APPLICATIONS
Antibodies
Conclusions