Kurzbeschreibung Das vor über einem Jahrhundert entdeckte Zentrosom ist das wichtigste Mikrotubuli-Organisationszentrum (MTOC) tierischer Zellen. Im Laufe der vergangenen Jahre ergaben intensive Forschungsarbeiten, dass sich Anomalien dieser Organellen in den meisten menschlichen Tumoren finden. Dieses hochaktuelle Buch fasst den gegenwärtigen Kenntnisstand zu Struktur, Aufbau und Funktion der Zentrosome sowie zu ihrer Bedeutung bei der Entwicklung bestimmter Krankheitsbilder zusammen und wird ein breites Leserspektrum - vom Zell- und Molekularbiologen bis zum Onkologen - interessieren.
Aus dem Inhalt Early Studies on Centrioles and Centrosomes (J. Gall) MICROTUBULE ORGANIZATION AND DYNAMICS The tubulin superfamily (T. Stearns) Microtubule nucleation (M. Moritz) The Budding Yeast Spindle Pole Body: A Centrosome Analog (M. Winey) Dissection of basal body and centriole function in the unicellular green alga Chlamydomonas reinhardtii (S. Dutcher) The Centrosome in evolution (M. Bornens) THE INTEGRATION OF CENTROSOME AND CHROMOSOME CYCLES A Proteomic approach to the inventory of the human centrosome (C. Wilkinson) The Role of the Centrosome in Cell Cycle progression (A. Fry) Centrosome duplication and its regulation in the higher animal cell (G. Sluder) A Synergy of Technologies: Using Green Fluorescent Protein Tagging and Laser Microsurgery to Study Centrosome Function and Duplication in Vertebrates (A. Khodjakov) Centrosome regulation in response to environmental and genotoxic stress (W. Theurkauf) THE CENTROSOME IN DEVELOPMENT AND TISSUE ARCHITECTURE The C. elegans centrosome during early embryonic development (A. Hyman) Centrosome in a developing organism: lessons from Drosophila (J. Raff) Centrosome inheritance during fertilization and cloning: implications for stem cell medicine and human reproduction (G. Schatten) Microtubule Organising Centres in Polarised Epithelial Cells (M. Mogensen) MICROTUBULE ORGANIZING CENTERS IN DISEASE Centrosome anomalies in cancer: from early observations to animal models (B. Brinkley) Radiation-therapy and centrosome anomalies in pancreatic cancers (N. Sato) Human papillomavirus infection and centrosome anomalies in cervical cancer (K. Münger) Interactions between centrosomes and viral and bacterial pathogens (M. Way) Basal bodies and microtubule organization in pathogenic protozoa (K. Gull)
