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23.12.2011
VIP: Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor
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08.12.2011
Roth Describes Changing Pharma Landscape as Patent Cliff Looms
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21.11.2011
VIP: Aspirin Analogues as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitors: Synthesis, Nitric Oxide Release, Molecular Modeling, and Biological Evaluation as Anti-Inflammatory Agents
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10.11.2011
Philip S. Portoghese, Editor-in-Chief of J. Med. Chem., Steps Down at the End of 2011
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04.11.2011
VIP: Huprine Derivatives as Sub-Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X-ray Crystallography
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18.10.2011
VIP: Development of Isoxazoline-Containing Peptidomimetics as Dual αvβ3 and α5β1 Integrin Ligands
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13.10.2011
2011 CNRS Bronze Medal Awarded to Karine Alvarez
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13.10.2011
Rainer Metternich to Lead the Small Molecules Research Program at Roche
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13.10.2011
VIP: Insights into Matriptase-2 Substrate Binding and Inhibition Mechanisms by Analyzing Active-Site-Mutated Variants
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13.10.2011
VIP: Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors
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13.10.2011
VIP: Understanding of Molecular Substructures that Contribute to hERG K+ Channel Blockade: Synthesis and Biological Evaluation of E-4031 Analogues
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11.10.2011
VIP: From a Library of MAG Antagonists to Nanomolar CD22 Ligands
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11.10.2011
VIP: From Catalysts to Bioactive Organometallics: Do Grubbs Catalysts Trigger Biological Effects?
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11.10.2011
VIP: Rofecoxib Analogues Possessing a Nitric Oxide Donor Sulfohydroxamic Acid (SO2NHOH) Cyclooxygenase-2 Pharmacophore: Synthesis, Molecular Modeling, and Biological Evaluation as Anti-inflammatory Agents
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11.10.2011
VIP: Urolithin as a Converging Scaffold Linking Ellagic Acid and Coumarin Analogues: Design of Novel Potent Protein Kinase CK2 Inhibitors
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08.10.2011
VIP: A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents
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08.10.2011
VIP: Exhaustive Fluorine Scanning toward Potent p53–Mdm2 Antagonists
|
08.10.2011
VIP: Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis
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05.10.2011
2011 Nobel Prize in Physiology or Medicine goes to Beutler, Hoffmann, Steinman
|
14.09.2011
VIP: Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3)
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29.08.2011
VIP: Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)
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28.07.2011
VIP: (S)- and (R)-Fluoxetine as Native Markers in MS Binding Assays Addressing the Serotonin Transporter
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14.07.2011
VIP: Synthesis and Structure–Activity Relationships of a Class of Sodium Iodide Symporter Function Inhibitors
|
05.07.2011
VIP: Cell-Free HIV-1 Virucidal Action by Modified Peptide Triazole Inhibitors of Env gp120
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16.06.2011
VIP: Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release
|
13.05.2011
VIP: Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors
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22.04.2011
World Malaria Day: April 25th
|
19.04.2011
VIP: Evidence for the Existence of a Specific G-Protein-Coupled Receptor Activated by Guanosine
|
19.04.2011
VIP: Inhibition of Histone Demethylases by 4-Carboxy-2,2'-Bipyridyl Compounds
|
07.04.2011
VIP: Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes
|
29.03.2011
ChemMedChem 04/2011: Women in Chemistry (IYC 2011)
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23.03.2011
World TB Day 2011: March 24
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17.03.2011
VIP: Hybrid Lipoic Acid Derivatives to Attack Prion Disease on Multiple Fronts
|
16.03.2011
VIP: Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption
|
11.03.2011
VIP: Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) γ/δ Agonists with High Potency and in vivo Efficacy
|
10.03.2011
VIP: Discovery and Biological Activity of 6BrCaQ as an Inhibitor of the Hsp90 Protein Folding Machinery
|
08.02.2011
ChemMedChem at the 10th Winter Conference on Medicinal and Bioorganic Chemistry, January 23–27, 2011, Steamboat Springs, Colorado (USA)
|
02.02.2011
ChemMedChem 02/2011: Rare and Neglected Diseases
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02.02.2011
VIP: BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution
|
25.01.2011
VIP: Pyrido[1,2-a]benzimidazole-Based Agents Active Against TB, MDR-TB, and XDR-TB
|
19.01.2011
VIP: A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors
|
16.01.2011
VIP: Revealing Atropisomer Axial Chirality in Drug Discovery
|
04.01.2011
ChemMedChem Gets a New Editor
|
11.11.2010
VIP: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity
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08.11.2010
VIP: Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1
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28.10.2010
ChemMedChem 11/2010: 25 Years of Anti-HIV Research
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26.10.2010
VIP: Asborin Inhibits Aldo/Keto Reductase 1A1
|
26.10.2010
VIP: Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue–Dendrimer Conjugate in C26 Tumor Bearing Mice
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26.10.2010
VIP: Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells
|
06.10.2010
VIP: Molecular Assembly of Multifunctional 99mTc Radiopharmaceuticals Using "Clickable" Amino Acid Derivatives
|
29.09.2010
VIP: Target Profiling of a Small Library of Phosphodiesterase 5 (PDE5) Inhibitors using Chemical Proteomics
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22.09.2010
Wiley and ChemMedChem at the International Symposium on Medicinal Chemistry 2010 in Brussels
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17.09.2010
VIP: Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors
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02.09.2010
VIP: Synthesis and Evaluation of Bombesin Analogues Conjugated to Two Different Triazolyl-Derived Chelators for 99mTc Labeling
|
30.08.2010
ChemMedChem 09/2010: Fighting Cancer
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19.08.2010
VIP: The Active Core in a Triazole Peptide Dual-Site Antagonist of HIV-1 gp120
|
09.08.2010
ChemMedChem Author Guidelines Updated!
|
03.08.2010
ChemMedChem's Success Recognized by Thompson Reuters: Editorial Team Interview Appears in ScienceWatch
|
03.08.2010
VIP: High-Resolution Crystal Structure of a Lasso Peptide
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03.08.2010
VIP: Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization
|
27.06.2010
VIP: Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors
|
17.06.2010
New 2009 Impact Factor: 3.232
|
17.06.2010
VIP: Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm
|
15.06.2010
VIP: Discovery of a Class of Diketopiperazines as Antiprion Compounds
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15.06.2010
VIP: Homology Modelling of the GABA Transporter and Analysis of Tiagabine Binding
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15.06.2010
VIP: HTS and Rational Drug Design to Generate a Class of 5-HT2C-Selective Ligands for Possible Use in Schizophrenia
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15.06.2010
VIP: Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)
|
15.06.2010
VIP: Jostling for Position: Optimizing Linker Location in the Design of Estrogen Receptor-Targeting PROTACs
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22.05.2010
Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2,4-Cyclodiphosphate Synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum
|
22.05.2010
VIP: The Role of Fluorine Atoms in a Fluorinated Prostaglandin Agonist
|
23.04.2010
Arun K. Ghosh Awarded the 2010 IUPAC-Richter Prize
|
12.04.2010
VIP: Design, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4-c]quinoline-1-one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors
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22.03.2010
VIP: Azides Derived from Colchicine and Their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug
|
18.03.2010
Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL
|
18.03.2010
VIP: A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety
|
18.03.2010
VIP: Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives
|
09.03.2010
VIP: Anticancer Activity of Vitamin E-Derived Compounds in Murine C6 Glioma Cells
|
23.01.2010
VIP: Lectin-Based Drug Design: Combined Strategy to Identify Lead Compounds using STD NMR Spectroscopy, Solid-Phase Assays, and Cell Binding for a Plant Toxin Model
|
15.01.2010
VIP: Pro-oxidant Properties of AZT and other Thymidine Analogues in Macrophages: Implication of the Azido Moiety in Oxidative Stress
|
15.01.2010
VIP: Selective Pharmacophore Models of Dopamine D1 and D2 Full Agonists Based on Extended Pharmacophore Features
|
15.01.2010
VIP: Upgrading a Natural Product: Inhibition of Human β-Tryptase by Cyclotheonamide Analogues
|
12.01.2010
New Editorial Board and International Advisory Board Members
|
12.01.2010
VIP: Chelator Fragment Libraries for Targeting Metalloproteinases
|
19.11.2009
Thalidomide: a Revival
|
13.11.2009
VIP: Comparison of Structure- and Ligand-Based Virtual Screening Protocols Considering Hit List Complementarity and Enrichment Factors
|
13.11.2009
VIP: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones
|
13.11.2009
VIP: How to Replace the Residual Solvation Shell of Polar Active Site Residues to Achieve Nanomolar Inhibition of tRNA-Guanine Transglycosylase
|
05.11.2009
VIP: Thermodynamic Optimisation in Drug Discovery: A Case Study using Carbonic Anhydrase Inhibitors
|
04.11.2009
Steven Ley Awarded the 2009 Heinrich Wieland Prize
|
27.10.2009
ChemMedChem 11/2009: Computer Power!
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22.10.2009
VIP: Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria
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29.09.2009
ChemMedChem 10/2009: Tackling Tumors!
|
31.08.2009
ChemMedChem 09/2009: Shockingly Hot!
|
25.06.2009
Going for Impact!
|
23.10.2008
Giordano Giacomello Medal to G. Tarzia
|
28.08.2008
Ley, Seeberger, and Kubinyi Awarded
|
08.10.2007
Nobel Prize in Physiology or Medicine 2007 to Capecchi, Evans, and Smithies
|
15.06.2007
ChemMedChem in Web of Science
|
01.12.2006
First Volume of ChemMedChem Completed
|
02.10.2006
RNA Interference Earns Fire, Mello Nobel Prize
|
11.07.2006
ChemMedChem now accepted in MEDLINE
|
04.10.2005
Nobel Prize in Medicine/Physiology to Marshall/Warren |
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