Public Health Genomics
The Essentials
Jossey-Bass Public Health/Health Services Text
1. Auflage Dezember 2008
304 Seiten, Softcover
Wiley & Sons Ltd
Kurzbeschreibung
The Institute of Medicine has declared the understanding of this topic an essential public health competency. This resource provides a comprehensive overview of the emerging and essential topic of genomics and genetics in public health. It examines the basic molecular genetics; principles of genetic epidemiology; ethical, legal, and social implications of genetics; and clinical applications to disease prevention throughout the life cycle. The book covers such key topics as History and Philosophy of Public Health Genetics; Genomics and Government; The Basic Science of Genetics; Polymorphisms and Gene-Environment Interactions; and much more.
Praise for Public Health Genomics
"This book is beautifully written for health professionals and students in the fields of public health, medicine, and genetics. Because of Dr. Mikail's ability to explain complex concepts clearly, it also effectively educates the community-at-large about core principles in genomics, increasing awareness in patients, families, and nonprofessionals alike."
--Samuel Rahbar, MD, PhD, professor, Department of Diabetes and Endocrinology, City of Hope National Medical Center
"Centered around CDC genomics competencies for public health professionals, Dr. Mikail's book provides a solid background in the core scientific and social issues surrounding public health genomics. As we strive to apply our understanding of genetics toward developing more effective disease prediction and prevention strategies for individuals and populations, students and practitioners will find this text an increasingly valuable resource in daily practice."
--R.J. Desnick, PhD, MD, professor and chairman, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York University
"One of the first of its kind, this book brilliantly integrates the previously disparate fields of genomics and public health in a well-written introductory text that is a must-read for students in public health, medicine, and anyone interested in the health profession."
--Barbara Nemesure, PhD, associate professor, Department of Preventive Medicine, State University of New York at Stony Brook
Foreword.
Preface.
The Authors.
Introduction.
PART ONE: SCIENTIFIC AND SOCIAL PERSPECTIVES ON GENOMICS.
CHAPTER ONE: PAST, PRESENT, AND FUTURE OF PUBLIC HEALTH GENOMICS.
History of Human Genetics.
History of Public Health Genetics.
Impact of Genetics on Primary, Secondary, and Tertiary Prevention.
Phenotypic versus Genotypic Prevention.
Genomics Today.
Genomics Tomorrow.
CHAPTER TWO: GENOMICS AND GOVERNMENT.
The NIH and the NHGRI.
The NOPHG.
The SACGHS.
State Government Programs.
Genomics and Bioterrorism Preparedness.
CHAPTER THREE: BASIC MOLECULAR GENETICS.
Hereditary Material.
DNA Replication.
Transcription and Translation.
Gene Expression.
Mutations and Polymorphisms.
CHAPTER FOUR: MUTATIONS, POPULATION GENETICS, AND ETHNICITY.
Somatic versus Germline Mutations.
Types of Mutations.
Causes of Mutations.
Population Genetics.
Race, Ethnicity, and Genomics.
CHAPTER FIVE: INHERITANCE PATTERNS AND FAMILY HISTORY.
Gregor Mendel and His Pea Plants.
Autosomes and Sex Chromosomes.
Drawing a Pedigree.
Non-Mendelian Inheritance Patterns.
Inheritance Patterns, Family History, and Public Health.
CHAPTER SIX: GENETIC EPIDEMIOLOGY AND GENE-ENVIRONMENT INTERACTIONS.
Review of Basic Concepts.
Polygenic and Multifactorial Traits.
Determining the Risk of Multifactorial Disorders.
Determining Genetic versus Environmental Effects.
Determining Patterns of Inheritance and Localizing Genes.
Gene-Environment Interactions and Molecular Epidemiology.
CHAPTER SEVEN: GENETIC INFORMATION, ETHICS, AND THE LAW.
Examples of Genetic Discrimination and Breach of Privacy.
Evolution of Privacy and Antidiscrimination Laws.
Genetics Research and Concern for Privacy.
Clinical Genetic Testing and the Duty to Inform.
PART TWO: GENOMICS IN MATERNAL, CHILD, AND ADULT HEALTH.
CHAPTER EIGHT: TOXICOLOGY, TERATOLOGY, AND PRENATAL DIAGNOSIS.
Birth Defects and Embryology.
Chromosomes.
Prenatal Diagnosis.
Preimplantation Genetic Diagnosis.
CHAPTER NINE: PRECONCEPTIONAL GENETIC SCREENING AND CULTURAL COMPETENCE.
Genetic Diseases Common among People of Ashkenazic Jewish Descent.
Genetic Diseases Common among People of Sephardic and Mizrahi Jewish Descent.
Reproductive Options for Carriers.
Limitations of Ethnically Based Genetic Screening.
CHAPTER TEN: METABOLIC DISORDERS AND NEWBORN SCREENING.
Newborn Screening's Relevance to Public Health.
Biology of Metabolic Disorders.
Newborn Screening in California.
MS/MS-Detectable Disorders.
CHAPTER ELEVEN: PEDIATRIC GENETICS AND HEALTH SUPERVISION.
American Academy of Pediatrics.
Achondroplasia.
Down Syndrome.
Fragile X Syndrome.
Marfan Syndrome.
Prader-Willi Syndrome.
Autism.
CHAPTER TWELVE: ADULT GENETICS, GENETIC COUNSELING, AND HEALTH BEHAVIOR.
Alzheimer's Disease.
Cardiovascular Disease.
Cancer.
Familial Cancer Syndromes.
Genetic Testing, Risk Perception, and Health Behavior.
PART THREE: AREAS OF GENERAL INTEREST.
CHAPTER THIRTEEN: HEALTH ECONOMICS, HEALTH DISPARITIES, AND GENETIC SERVICES.
Basics of Health Economics.
Health Economics of Genetic Screening.
Health Care Disparities.
CHAPTER FOURTEEN: GENOMICS AND COMMUNICABLE DISEASE CONTROL.
Bacteria.
Viruses.
Genomics of a Pandemic.
CHAPTER FIFTEEN: HOT TOPICS IN GENOMICS.
Personalized Medicine.
Gene Therapy.
Stem Cell Research.
CHAPTER SIXTEEN: BIOINFORMATICS AND GENOMICS ONLINE.
Clinical and Community Resources.
Ethical, Legal, and Social Issues.
Genetic Epidemiology.
Government Agencies.
Maternal and Child Health.
Professional Genetics Education.
Professional Genetics Societies.
Professional Public Health Societies.
Research Resources.
Appendix 1: Answers to Selected Discussion Questions.
Glossary.
References.
Name Index.
Subject Index.
