Asymmetric Synthesis of Nitrogen Heterocycles

Royer, Jacques (Herausgeber)

1. Auflage März 2009
XVI, 409 Seiten, Hardcover
19 Abbildungen
1 Tabellen
Monographie

ISBN: 978-3-527-32036-3

Wiley-VCH, Weinheim

Wiley Online Library Inhalt Probekapitel

Kurzbeschreibung

With all aspects of the topic presented in a compact manner, this book is clearly structured, such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications.

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Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections -- asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom -- such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications.
Essential for synthetic chemists in pharmaceutical and agrochemical chemistry.

PART 1: Asymmetric Synthesis of Nitrogen Heterocycles Containing Only One Heteroatom

ASYMMETRIC SYNTHESIS OF THREE- AND FOUR-MEMBERED RING HETEROCYCLES
Substituted Aziridines
Substituted Monocyclic Azetidines and Carbocyclic-Fused Systems
ASYMMETRIC SYNTHESIS OF FIVE-MEMBERED RING HETEROCYCLES
Monocyclic Pyrrolidines and Pyrrolidinones
Pyrrolines
Fused Bicyclic Systems with Bridgehead Nitrogen
ASYMMETRIC SYNTHESIS OF SIX-MEMBERED RING HETEROCYCLES
Introduction
Dihydropyridines
Tetrahydropyridines
Monocyclic Piperidines and Carbocyclic Fused Systems
Fused Tri- or Bicyclic System with Bridgehead Nitrogen
ASYMMETRIC SYNTHESIS OF SEVEN- AND MORE-MEMBERED RING HETEROCYCLES
Substituted Azepines
Substituted Azocines
Substituted Large Nitrogen-Containing Rings

PART 2: Asymmetric Synthesis of Nitrogen Heterocycles With More Than One Heteroatom

ASYMMETRIC SYNTHESIS OF THREE- AND FOUR-MEMBERED RING HETEROCYCLES WITH MORE THAN ONE HETEROATOM
Introduction
Three-Membered N-Heterocycles with Two Heteroatoms
Four-Membered N-Heterocycles with Two Heteroatoms
ASYMMETRIC SYNTHESIS OF FIVE-MEMBERED RING HETEROCYCLES WITH MORE THAN ONE HETEROATOM
Five-Membered Heterocycles with N and O Atoms
Five-Membered Heterocycles with Two N Atoms
Five-Membered Heterocycles with N and S Atoms
ASYMMETRIC SYNTHESIS OF SIX-MEMBERED RING NITROGEN HETEROCYCLES WITH MORE THAN ONE HETEROATOM
Six-Membered Rings with Another Heteroatom in the Same Ring
ASYMMETRIC SYNTHESIS OF SEVEN-MEMBERED RINGS WITH MORE THAN ONE HETEROATOM
Diazepines
Oxazepines
Thiazepines

Jacques Royer is Director of Research at the CNRS. He is currently the head of a laboratory of medicinal chemistry at the University Paris Descartes. He got his PhD at the University of Paris-Sud Orsay, and worked for 18 years at the Institut de Chimie des Substances Naturelles at the CNRS in Gif-sur-Yvette in the group of Prof. Henri-Philippe Husson. His research areas are asymmetric synthesis of natural products and more particularly alkaloids, amino alcohols and amino acids as well as original methods of synthesis including electrosynthesis. He is the author of about 100 publications in international renowned journals.

J. Royer, Faculté de Pharmacie, 4 avenue de l'Observatoire, Paris