Biocatalysis for Green Chemistry and Chemical Process Development
1. Auflage August 2011
496 Seiten, Hardcover
Fachbuch
Kurzbeschreibung
Biocatalysis is emerging as a transformational technology uniquely suited to deliver green chemistry solutions for chemical synthesis. Focusing exclusively on biocatalytic processes, this book provides a comprehensive overview of green chemistry applications of enzyme-driven transformations for a wide range of industries. Including a variety of case studies, the book demonstrates the application of biocatalysis across a wide range of chemical manufacturing fields, and why it is a good sustainable manufacturing option. An important resource for pharmaceutical manufacturers and chemists as well as biorenewable energy scientists.
This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials.
The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.
Preface xi
Part I. Introduction Chapters 1
1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3
2. How Green Can the Industry Become with Biotechnology? 23
3. Emerging Enzymes and Their Synthetic Applications 45
4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67
Part II. Application and Case Studies-Pharmaceuticals and Fine Chemicals 89
5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91
6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151
7. Microbial Production of Plant-Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173
8. Toward Greener Therapeutic Proteins 197
Part III. Application and Case Studies-Flavor & Fragrance, Agrochemicals and Fine Chemicals 221
9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223
10. Application of Biocatalysis in the Agrochemical Industry 255
11. Green Porduction of Fine Chemicals by Isolated Enzymes 277
12. Whole Cell Production of Fine Chemicals and Intermediates 299
Part IV. Application and Case Studies-Polymers and Renewable Chemicals 327
13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329
14. Enzymatic Degradation of Lignocellulosic Biomass 361
15. Bioconversion of Nenewables-Plant Oils 391
16. Microbial Bioprocesses for industrial-Scale Chemical Production 429
Index 469
ROMAS JOSEPH KAZLAUSKAS is Professor of Biochemistry, Molecular Biology and Biophysics at the BioTechnology Institute of the University of Minnesota, Twin Cities. He is the coauthor of over eighty papers and reviews, and the book Hydrolases in Organic Synthesis. He also served as the co-chair of two Gordon Research Conferences, one on biocatalysis and one on green chemistry.
