Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257

Tight junctions between epithelial and endothelial cells formselective barriers and paracellular channels and regulateparacellular transport of solutes, immune cells, and drugs. Morespecifically, tight junctions consist of proteins that laterallyinterconnect neighboring cells of epithelia and endothelia. Certainproteins seal the tight junction, so that a nearly impermeablebarrier develops, whereas others form channels that allow forpermeation between the cells. Recent investigations have focused ontight junction proteins, belonging to the claudin family(claudins-1 to -27 in humans) and the newly defined group of TAMP(three proteins: occludin, Marvel-D2, and tricellulin). Barriers and Channels Formed by Tight Junction Proteins Ishowcases work in this area clustered around three major themes:the molecular properties of tight junctions, for example, the roleof the claudin family of proteins and the formation of ion andcharge-selective channels; the regulation of tight junction andbarrier functions via genetic mechanisms and scaffold proteinmediation; and the functional role of the tight junction in varioustissues, such as the skin, lungs, endothelia, and nervoussystem

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