Stem Cell Biology
Development and Plasticity, Volume 1049
Annals of the New York Academy of Sciences
Stem cells have generated considerable interest recently in the
scientific, clinical, and public arenas. It is essential that we
gain a broader understanding of the factors that regulate the
biology of stem cells: their ability for self-renewal,
differentiation, and plasticity, as well as the differences between
embryonic and adult stem cells. And to learn whether stem cells can
be manipulated to replace cells in diseased tissues depends on
better understanding their normal developmental properties.
This volume offers contributions from numerous interdisciplinary
areas bridging biotechnology and biomedical sciences. The ability
to isolate and maintain pluripotent stem cells in culture offers
exciting possibilities for replacing damaged or diseased organs and
tissues. Moreover, stem cells will provide opportunities for major
advances in our understanding of fundamental developmental
processes.
The study of pluripotent stem cells derived from early embryos
or fetal tissues has shown that they are capable of replicating
indefinitely in vitro and possess the ability to differentiate into
many cell types. Biotechnological advances under which growth
conditions and factors can be identified and characterized are
needed to guide such cells to form organ-specific tissues.
Biomedical researchers are also investigating approaches to
isolate and manipulate adult-derived multipotential stem cells that
appear to possess considerably broader differentiation capacity
than originally imagined.
Novel therapeutic strategies are being developed to take
advantage of the ability of stem cells to proliferate in culture
and to survive after transplantation into various tissues, where
they may integrate and stably express foreign genes, or repopulate
damaged or diseased organs such as the heart, brain, or
pancreas.
These presentations foster a broader understanding of the
factors that regulate the biology and plasticity of stem cells
through the picture they provide of the "state of the science" of
stem cell biology and by framing the many questions that remain to
be answered.
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Sakaguchi, and Marit Nilsen-Hamilton.
Part I: Regional Determinants of Cell Fate:.
1. Oxygen in the Cultivation of Stem Cells. By Marie Csete.
2. DNA Damage-Induced Programmed Cell Death: Potential Roles in
Germ Cell Development. By Yukiko Yamada and Clark R. Coffman.
.
Part II: Intrinsic Determinants of Stem Cells:.
3. G Protein-Coupled Receptor Roles in Cell Migration and Cell
Death Decisions: Angela R. Kamps and Clark R. Coffman.
4. Growth and Differentiation of Astrocytes and Neural
Progenitor Cells on Micropatterned Polymer Films: Jennifer B.
Recknor, D S. Sakaguchi, and S K. Mallapragada.
5. Cellular and Molecular Regulation of Hematopoietic and
Intestinal Stem Cell Behavior: Xi C. He, Jiwang Zhang, and Linheng
Li.
6. The Function of the Neuronal Proteins Shc and Huntingtin in
Stem Cells and Neurons: Pharmacologic Exploitation for Human Brain
Diseases: Chiara Zuccato, Luciano Conti, Erika Reitano, Marzia
Tartari, and Elena Cattaneo.
7. Engineering a Dopaminergic Phenotype in Stem/Precursor Cells:
Role of Nurr1, Glia-Derived Signals, and Wnts: Ernest Arenas.
.
Part III: Transdifferentiation:.
8. Umbilical Cord Blood-Derived Stem Cells and Brain Repair:
Paul R. Sanberg, Alison E. Willing, Svitlana Garbuzova-Davis,
Samuel Saporta, Guoqing Liu, Cyndy Davis Sanberg, Paula C.
Bickford, Stephen K. Klasko, and Nagwa S. El-Badri.
9. Infusion of Human Umbilical Cord Blood Ameliorates Neurologic
Deficits in Rats with Hemorrhagic Brain Injury: Zhenhong Nan,
andrew Grande, Cyndy D. Sanberg, Paul R. Sanberg, and Walter C.
Low.
10. How Wnt Signaling Affects Bone Repair by Mesenchymal Stem
Cells from the Bone Marrow: Carl A. Gregory, William G. Gunn,
Emigdio Reyes, Angela J. Smolarz, James Munoz, Jeffrey L. Spees,
and Darwin J. Prockop.
.
Part IV: Stem Cell Responses to Perturbation:.
11. Human Retinal Progenitor Cells Grown as Neurospheres
Demonstrate Time-Dependent Changes in Neuronal and Glial Cell Fate
Potential: David M. Gamm, Aaron D. Nelson, and Clive N.
Svendsen.
12. Neural Progenitor Cell Transplants into the Developing and
Mature Central Nervous System: D S. Sakaguchi, S J. Van Hoffelen, S
D. Grozdanic, Y H. Kwon, R H. Kardon, and M J. Young.
13. Stem Cells for Retinal Degenerative Disorders: Jason S.
Meyer, Martin L. Katz, and Mark D. Kirk.
14. Magnetic Resonance Tracking of Implanted Adult and Embryonic
Stem Cells in Injured Brain and Spinal Cord: Eva Syková and
Pavla Jendelová.
15. The Miniature Pig as an Animal Model in Biomedical Research:
Petr Vodicka, Karel Smetana, Jr., Barbora Dvoránková,
Teresa Emerick, Yingzhi Z. Xu, Jitka Ourednik, Václav
Ourednik, and Jan Motlík.
.
Part V: Reciprocal Communication between Graft and
Host:.
16. Graft/Host Relationships in the Developing and Regenerating
CNS of Mammals: Václav Ourednik and Jitka Ourednik.
17. Grafted Neural Stem Cells Shield the Host Environment from
Oxidative Stress: Lalitha Madhavan, Václav Ourednik, and Jitka
Ourednik.
18. Administration of Allogenic Stem Cells Dosed to Secure
Cardiogenesis and Sustained Infarct Repair: Atta Behfar, Denice M.
Hodgson, Leonid V. Zingman, Carmen Perez-Terzic, Satsuki Yamada,
Garvan C. Kane, Alexey E. Alekseev, Michel Pucéat, and andre
Terzic.
Index of Contributors
