The Tumour Microenvironment
Causes and Consequences of Hypoxia and Acidity. No. 240
Novartis Foundation Symposium (Band Nr. 240)
1. Auflage Oktober 2001
X, 304 Seiten, Hardcover
Handbuch/Nachschlagewerk
Kurzbeschreibung
Ergebnisse von in vitro-Studien lassen vermuten, dass sich der pH-Wert in einem Tumor auf die Wirksamkeit von Chemo- oder Strahlentherapien auswirken kann. Wie aber sieht die Beziehung zwischen der Tumorentwicklung und dem pH-Wert aus? Können ein niedriger pH-Wert oder ein Sauerstoffmangel die Carcinogenese hemmen? Wo bieten sich therapeutische Ansätze? Anwort auf diese und andere Fragen finden Sie in diesem Band. In interdisziplinärer Weise wurden Beiträge aus der Grundlagenforschung und der klinischen Praxis zusammengetragen.
Several fundamentally important questions form the basis for this book. What are the relationships between tumour perfection and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH?
It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumourigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo and radiotherapy. By considering the consequences of, or manipulation of pH, more
effective tharapies may be realised.
Frontiers in the Measurement of Cell and Tissue pH (Robert J Gillies and Ronald M Lynch).
The Physiological Environment in Cancer Vascularization, Invasion and Metastasis (Zaver M Bhujwalla et al).
Why are Cancers Acidic? A Carrier-Mediated Diffusion Model for H+ Transport in the Interstitial Fluid (J R Griffiths et al).
pH and Therapy of Human Cancers (Jeffrey L Evelhoch).
Mathematical Models of Tumour Invasion Mediated by Transformation-Induced Alteration of Microenvironmental pH (Robert A Gatenby and Edward T Gawlinski).
pH Regulation of Renal Gene Expression (Norman P Curthoys et al)).
Genetic Determinants that influence Hypoxia-Induced Apoptosis (Rodolfo M Alarcon et al).
Genomic Instability in Cancer (Sara Rockwell et al).
pH, Hypoxia and Metastasis (R P Hill et al).
Modelling Tumour Acidity and Invasion (Steven D Webb et al).
pH, Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth (Jacques Pouyssé gur et al).
pH and Chemotherapy (Natarajan Raghunand).
The HIF Pathway: Implications for Patterns of Gene Expression in Cancer (Charles C Wykoff et al).
pH and Multidrug Resistance (Paul D Roepe).
'The Metabolism of Tumours' 70 Years Later (Gregg L Semenza et al).
The Multiple Mechanisms of Multidrug Resistance and Cellular pH (Sanford Simon).
Summing Up (Robert J Gillies).
Index of Contributors.
Subject Index.
